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410957 3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem

3-Isobutyl-1-methylxanthine, CAS 28822-58-4, is a cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: IBMX

Primary Target: cAMP and cGMP phosphodiesterases
410957
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
28822-58-4C₁₀H₁₄N₄O₂

Products

RéférenceConditionnement Qté
410957-1GM Ampoule plast. 1 gm
410957-250MG Ampoule plast. 250 mg
Description
OverviewA cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNF-α expression in adipocyte precursor cells.
Catalogue Number410957
Brand Family Calbiochem®
SynonymsIBMX
References
ReferencesHube, F., et al. 1999. Horm. Metab. Res. 31, 359.
Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.
Product Information
CAS number28822-58-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₁₄N₄O₂
Chemical formulaC₁₀H₁₄N₄O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Application3-Isobutyl-1-methylxanthine, CAS 28822-58-4, is a cell-permeable, non-specific inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM).
Biological Information
Primary TargetcAMP and cGMP phosphodiesterases
Primary Target IC<sub>50</sub>2-50 µM against cAMP and cGMP phosphodiesterases
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSZD8500000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
410957-1GM 04055977211139
410957-250MG 04055977211146

Documentation

3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

3-Isobutyl-1-methylxanthine - CAS 28822-58-4 - Calbiochem Certificats d'analyse

TitreNuméro de lot
410957

Références bibliographiques

Aperçu de la référence bibliographique
Hube, F., et al. 1999. Horm. Metab. Res. 31, 359.
Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.

Brochure

Titre
Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-July-2013 JSW
SynonymsIBMX
DescriptionA non-specific, cell-permeable inhibitor of cAMP and cGMP phosphodiesterases (IC50 = 2-50 µM). Also acts as an adenosine receptor antagonist. Reported to inhibit TNFα expression in adipocyte precursor cells.
FormWhite solid
CAS number28822-58-4
RTECSZD8500000
Chemical formulaC₁₀H₁₄N₄O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mM), Ethanol (10 mg/ml), or Methanol (50 mg/ml). Heating may be required to achieve complete solubilization.
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution in ethanol or methanol, refrigerate (4°C). Following reconstitution in DMSO, aliquot and freeze (-20°C). Ethanol/methanol and DMSO stock solutions are stable for up to 6 months at 4°C or -20°C, respectively.
Toxicity Standard Handling
ReferencesHube, F., et al. 1999. Horm. Metab. Res. 31, 359.
Morgan, A.J., et al. 1993. Biochem. Pharmacol. 45, 2373.
Scamps, F., et al. 1993. Eur. J. Pharmacol. 244, 119.
Turner, N.C., et al. 1993. Br. J. Pharmacol. 108, 876.
Tamura, T., et al. 1991. J. Gen. Physiol. 98, 95.
Beavo, J.A., and Reifsnyder, D.H. 1990. Trends Pharmacol. Sci. 11, 150.
Russell, T.R. 1979. Proc. Natl. Acad. Sci. USA 76, 4451.