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288104 2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem

Cell-permeable, non-competitive adenylate cyclase inhibitor (IC₅₀ = 3 µM), that binds to the adenosine P1 binding site.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2ʹ,5ʹ-dd-Ado

Primary Target: adenylate cyclase
288104
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
6698-26-6C₁₀H₁₃N₅O₂

Products

RéférenceConditionnement Qté
288104-1MG Ampoule plast. 1 mg
Description
OverviewCell-permeable, non-competitive adenylate cyclase inhibitor (IC50 = 3 µM), that binds to the adenosine P1 binding site. Blocks positive inotropic and chronotropic effects of β-adrenergic agents.
Catalogue Number288104
Brand Family Calbiochem®
Synonyms2ʹ,5ʹ-dd-Ado
References
ReferencesIbrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.
Product Information
CAS number6698-26-6
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₀H₁₃N₅O₂
Chemical formulaC₁₀H₁₃N₅O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetadenylate cyclase
Primary Target IC<sub>50</sub>3 µM against adenylate cyclase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
288104-1MG 04055977197914

Documentation

2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem Certificats d'analyse

TitreNuméro de lot
288104

Références bibliographiques

Aperçu de la référence bibliographique
Ibrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.

Brochure

Titre
Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-June-2008 RFH
Synonyms2ʹ,5ʹ-dd-Ado
DescriptionMembrane-permeable adenylate cyclase inhibitor that binds non-competitively to the enzyme via the P-site. Its inhibitory effect varies widely among tissues (IC50 = 3 µM for detergent solubilized rat brain membranes; IC50 = 45 µM for purified bovine brain enzyme). Blocks the forskolin-induced activation of adenylate cyclase activity (IC50 = 540 µM) in cultured bovine aortic endothelial cells. Also blocks the positive ionotropic and chronotropic effects of β-adrenergic agents.
FormWhite solid
CAS number6698-26-6
Chemical formulaC₁₀H₁₃N₅O₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesIbrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.