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100068 17-AAG - CAS 75747-14-7 - Calbiochem

A less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus.

17-AAG - CAS 75747-14-7 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: NSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin

Primary Target: Hsp90
100068
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
75747-14-7C₃₁H₄₃N₃O₈

Products

RéférenceConditionnement Qté
100068-500UG Ampoule plast. 500 μg
Description
OverviewA less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Induces apoptosis and displays antitumor effects (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53 (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways. Also sensitizes cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380) and downregulates vascular endothelial growth factor expression.
Catalogue Number100068
Brand Family Calbiochem®
SynonymsNSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
References
ReferencesBasso, A.D., et al. 2002. Oncogene 21, 1159.
Clarke, P.A., et al. 2002. Oncogene 19, 4125.
Clarke, P.A., et al. 2000. Oncogene 19, 4125.
Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
Product Information
CAS number75747-14-7
ATP CompetitiveN
FormPurple solid
Hill FormulaC₃₁H₄₃N₃O₈
Chemical formulaC₃₁H₄₃N₃O₈
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHsp90
Primary Target IC<sub>50</sub>EC50 = 7.2 µM for Hsp90
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
100068-500UG 04055977226881

Documentation

17-AAG - CAS 75747-14-7 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

17-AAG - CAS 75747-14-7 - Calbiochem Certificats d'analyse

TitreNuméro de lot
100068

Références bibliographiques

Aperçu de la référence bibliographique
Basso, A.D., et al. 2002. Oncogene 21, 1159.
Clarke, P.A., et al. 2002. Oncogene 19, 4125.
Clarke, P.A., et al. 2000. Oncogene 19, 4125.
Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.

Fiche technique

Titre
Data Sheet 1.00068.0500

Manuels d'utilisation

Titre
Bouillon Bolton Sélectif Supplément 1.00079.0010
Pack insert Bolton Broth Selective Supplement 1.00079.0010
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-October-2007 RFH
SynonymsNSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
DescriptionA less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Reported to induce apoptosis and exhibit anti-tumor properties (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53, (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt. Hence, inhibits the Ras/Raf/MEK and PI3-Kinase signaling pathways. Shown to sensitize cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380), and down-regulates vascular endothelial factor expression.
FormPurple solid
Intert gas (Yes/No) Packaged under inert gas
CAS number75747-14-7
Chemical formulaC₃₁H₄₃N₃O₈
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml) or Methanol (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBasso, A.D., et al. 2002. Oncogene 21, 1159.
Clarke, P.A., et al. 2002. Oncogene 19, 4125.
Clarke, P.A., et al. 2000. Oncogene 19, 4125.
Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.

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Catégories

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Heat Shock Protein Inhibitors