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178251 α₁-Antitrypsin, Human Plasma - CAS 9041-92-3 - Calbiochem

α₁-Antitrypsin, CAS 9041-92-3, is a protease inhibitor of the serpin superfamily. Inhibits elastase, cathepsin G, and proteinase 3.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: α₁-AT, α₁-Proteinase Inhibitor, 3.5S α₁-Glycoprotein

Primary Target: serine proteases
178251
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #
9041-92-3

Products

RéférenceConditionnement Qté
178251-1MG Flacon en verre 1 mg
178251-5MG Ampoule plast. 5 mg
Description
OverviewA single polypeptide chain of 394 amino acids and three carbohydrate side chains linked to asparagine residues present at about 290 mg/100 ml in acute phase plasma. Serine protease inhibitor that also acts as a major physiological regulator of elastase. Inhibitor of neutrophil elastase, cathepsin G, and proteinase 3.
Catalogue Number178251
Brand Family Calbiochem®
Synonymsα₁-AT, α₁-Proteinase Inhibitor, 3.5S α₁-Glycoprotein
References
ReferencesCoakley, R.J., et al. 2001. Am. J. Med. Sci. 321, 33.
Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem. 52, 655.
Product Information
CAS number9041-92-3
Activity≥75% inhibition with active-site titrated porcine trypsin using benzoyl-Arg-p-nitroanilide (Bz-Arg-pNA) as the substrate.
ATP CompetitiveN
FormSolid
FormulationLyophilized from 300 mM NaCl, 30 mM sodium phosphate buffer, pH 6.5.
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary Targetserine proteases
Purity≥95% by SDS-PAGE
SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
178251-1MG 07790788059835
178251-5MG 04055977223132

Documentation

α₁-Antitrypsin, Human Plasma - CAS 9041-92-3 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

α₁-Antitrypsin, Human Plasma - CAS 9041-92-3 - Calbiochem Certificats d'analyse

TitreNuméro de lot
178251

Références bibliographiques

Aperçu de la référence bibliographique
Coakley, R.J., et al. 2001. Am. J. Med. Sci. 321, 33.
Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem. 52, 655.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-April-2008 RFH
Synonymsα₁-AT, α₁-Proteinase Inhibitor, 3.5S α₁-Glycoprotein
DescriptionA single polypeptide chain of 394 amino acids and three carbohydrate side chains linked to asparagine residues. Present at about 290 mg/100 ml in acute phase plasma. Serine protease inhibitor that also acts as a major physiological regulator of elastase.
FormSolid
FormulationLyophilized from 300 mM NaCl, 30 mM sodium phosphate buffer, pH 6.5.
SourcePrepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number9041-92-3
Purity≥95% by SDS-PAGE
Activity≥75% inhibition with active-site titrated porcine trypsin using benzoyl-Arg-p-nitroanilide (Bz-Arg-pNA) as the substrate.
SolubilityH₂O. Please refer to vial label for lot-specific volume prior to lyophilization.
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
Toxicity Standard Handling
Merck USA index14, 719
ReferencesCoakley, R.J., et al. 2001. Am. J. Med. Sci. 321, 33.
Travis, J., and Salvesen, G.S. 1983. Annu. Rev. Biochem. 52, 655.