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565792 γ-Secretase Inhibitor XXIII, Aβ42-Selective - Calbiochem

The γ-Secretase Inhibitor XXIII, Aβ42-Selective controls the biological activity of γ-Secretase.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
565792
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₃₀H₃₉N₇O

Products

RéférenceConditionnement Qté
565792-5MG Flacon en verre 5 mg
Description
OverviewA cell-permeable purine compound that acts as a highly potent and selective inhibitor against γ-secretase-mediated production of Aβ42 over Aβ40 (IC50 = 21 and 350 nM, respectively) and Notch1 (Notch IC50/ Aβ42 IC50 >2400) in cultures in vitro. Reported to be blood-brain barrier-permeant and orally bioavailable in APP-YAC transgenic mice and effectively reduce Aβ42 (by 73%), but not Aβ40, level in brain (100 mg/kg, p.o.) in vivo.
Catalogue Number565792
Brand Family Calbiochem®
References
ReferencesRivkin, A., et al. 2010. Bioorg. Med. Chem. Lett. 20, 2279.
Product Information
FormBeige solid
Hill FormulaC₃₀H₃₉N₇O
Chemical formulaC₃₀H₃₉N₇O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
565792-5MG 04055977191882

Documentation

γ-Secretase Inhibitor XXIII, Aβ42-Selective - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

γ-Secretase Inhibitor XXIII, Aβ42-Selective - Calbiochem Certificats d'analyse

TitreNuméro de lot
565792

Références bibliographiques

Aperçu de la référence bibliographique
Rivkin, A., et al. 2010. Bioorg. Med. Chem. Lett. 20, 2279.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-June-2011 JSW
DescriptionA cell-permeable purine compound that acts as a highly potent and selective inhibitor against γ-secretase-mediated production of Aβ42 over Aβ40 (IC50 = 21 and 350 nM, respectively) and Notch1 (Notch IC50/ Aβ42 IC50 >2400) in cultures in vitro. Reported to be blood-brain barrier-permeant and orally bioavailable in APP-YAC transgenic mice and effectively reduce Aβ42 (by 73%), but not Aβ40, level in brain (100 mg/kg, p.o.) in vivo.
FormBeige solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₀H₃₉N₇O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Toxicity Standard Handling
ReferencesRivkin, A., et al. 2010. Bioorg. Med. Chem. Lett. 20, 2279.