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565789 γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem

This γ-secretase inhibitor, CAS 209984-56-5, is a cell-permeable dibenzazepine compound that lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine

Primary Target: γ-secretase
565789
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
209984-56-5C₂₆H₂₃F₂N₃O₃

Products

RéférenceConditionnement Qté
565789-1MG Flacon en verre 1 mg
565789-500UG Ampoule plast. 500 μg
Description
OverviewA cell-permeable dibenzazepine (dbz) compound that acts as a potent γ-secretase inhibitor and significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50 = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10 µmol/kg, i.p).
Catalogue Number565789
Brand Family Calbiochem®
Synonyms(S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine
References
ReferencesDroy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.
van Es, J.H., et al. 2005. Nature 435, 959.
Milano, J., et al. 2004. Toxicol. Sci. 82, 341.
Product Information
CAS number209984-56-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₆H₂₃F₂N₃O₃
Chemical formulaC₂₆H₂₃F₂N₃O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetγ-secretase
Primary Target IC<sub>50</sub>1.7 nM inhibiting Notch processing in SupT1 cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
565789-1MG 04055977191837
565789-500UG 04055977191844

Documentation

γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

γ-Secretase Inhibitor XX - CAS 209984-56-5 - Calbiochem Certificats d'analyse

TitreNuméro de lot
565789

Références bibliographiques

Aperçu de la référence bibliographique
Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.
van Es, J.H., et al. 2005. Nature 435, 959.
Milano, J., et al. 2004. Toxicol. Sci. 82, 341.

Citations

Titre
  • Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.
    		•
    Fiche technique

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision28-February-2012 RFH
    Synonyms(S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine
    DescriptionA cell-permeable, potent γ-secretase inhibitor that significantly lowers both brain and plasma Aβ40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100 µmol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50 = 1.7 nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10 µmol/kg, i.p).
    FormWhite solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number209984-56-5
    Chemical formulaC₂₆H₂₃F₂N₃O₃
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMSO (10 mg/ml)
    Storage Protect from light
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesDroy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.
    van Es, J.H., et al. 2005. Nature 435, 959.
    Milano, J., et al. 2004. Toxicol. Sci. 82, 341.
    Citation
  • Droy-Dupré, L., et al. 2012. Dis. Model Mech. 5, 107.
    		•