565788 Sigma-Aldrichβ-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem
β-Secretase Inhibitor IV, CAS 797035-11-1, is a cell-permeable inhibitor that binds to BACE-1 active site and blocks its proteolytic activity (IC₅₀ = 15 nM for human BACE-1).
More>> β-Secretase Inhibitor IV, CAS 797035-11-1, is a cell-permeable inhibitor that binds to BACE-1 active site and blocks its proteolytic activity (IC₅₀ = 15 nM for human BACE-1). Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: BACE Inhibitor C3
Produits recommandés
Aperçu
| Replacement Information |
|---|
Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 797035-11-1 | C₃₁H₃₈N₄O₅S |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 565788-1MG | Ampoule plast. | 1 mg |
| Description | |
|---|---|
| Overview | A cell-permeable isophthalamide compound containing hydroxyethylamine motif that binds to BACE-1 active site and potently blocks its proteolytic activity (IC50 = 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells). Displays greater selectivity over other aspartyl proteases (IC50 = 0.23 µM, 7.6 µM and >50 µM for BACE-2, cathepsin D, and renin, respectively). Also available as a 10 mM solution in DMSO (Cat. No. 565794). Please note that the molecular weight for this compound is batch-specific due to variable water content. |
| Catalogue Number | 565788 |
| Brand Family | Calbiochem® |
| Synonyms | BACE Inhibitor C3 |
| References | |
|---|---|
| References | Halima, S.B., et al. 2016. Cell Reports. 14, In press. Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447. |
| Product Information | |
|---|---|
| CAS number | 797035-11-1 |
| ATP Competitive | N |
| Form | White solid |
| Hill Formula | C₃₁H₃₈N₄O₅S |
| Chemical formula | C₃₁H₃₈N₄O₅S |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
|---|---|
| Application Comments | Solubilize in DMSO (10 mg/ml), aliquot & store at -20*C; stable for 3 months. |
| Biological Information | |
|---|---|
| Primary Target | BACE-1 human |
| Primary Target IC<sub>50</sub> | 15 nM for BACE-1, human and 29 nM for sAPP_NF in HEK293-APPNFEV cells |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 565788-1MG | 04055977191820 |
Documentation
β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem FDS
| Titre |
|---|
β-Secretase Inhibitor IV - CAS 797035-11-1 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
|---|---|
| 565788 |
Références bibliographiques
| Aperçu de la référence bibliographique |
|---|
| Halima, S.B., et al. 2016. Cell Reports. 14, In press. Stachel, S.J., et al. 2004. J. Med. Chem. 47, 6447. |