219330 Sigma-Aldrichβ-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem
The β-Catenin/Tcf Inhibitor, FH535, also referenced under CAS 108409-83-2, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Cell Signaling applications.
More>> The β-Catenin/Tcf Inhibitor, FH535, also referenced under CAS 108409-83-2, controls the biological activity of β-Catenin/Tcf. This small molecule/inhibitor is primarily used for Cell Signaling applications. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: Wnt Pathway Inhibitor IX, N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide
Produits recommandés
Aperçu
| Replacement Information |
|---|
Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 108409-83-2 | C₁₃H₁₀Cl₂N₂O₄S |
Products
| Référence | Conditionnement | Qté | |
|---|---|---|---|
| 219330-10MG | Ampoule plast. | 10 mg |
| Description | |
|---|---|
| Overview | A cell-permeable sulfonamide compound that acts as a dual pathway inhibitor against Wnt/β-catenin (≥80% inhibition at 15 µM in β-catenin/Tcf-dependent cellular reporter assays) and PPARγ/δ (≥30% inhibition at 0.5 µM in PPRE cellular reporter assays) signalings. Although both FH535 and the structurally similar PPARγ-selective inhibitor GW9662 (Cat. No. 370700) inhibit coactivator/PPAR binding, only FH535 blocks β-catenin/PPARγ interaction and the antagonistic activity of FH535 does not involve the covalent modification of or non-covalent interaction with the PPAR ligand-binding site cystein residue that is crucial for GW9662 action. |
| Catalogue Number | 219330 |
| Brand Family | Calbiochem® |
| Synonyms | Wnt Pathway Inhibitor IX, N-(2-Methyl-4-nitro)-2,4-dichlorosulfonamide |
| References | |
|---|---|
| References | Handeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521. |
| Product Information | |
|---|---|
| CAS number | 108409-83-2 |
| Form | Yellow solid |
| Hill Formula | C₁₃H₁₀Cl₂N₂O₄S |
| Chemical formula | C₁₃H₁₀Cl₂N₂O₄S |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
|---|
| Biological Information | |
|---|---|
| Purity | ≥99% by HPLC |
| Physicochemical Information |
|---|
| Dimensions |
|---|
| Materials Information |
|---|
| Toxicological Information |
|---|
| Safety Information according to GHS |
|---|
| Safety Information |
|---|
| Product Usage Statements |
|---|
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
|---|
| Supplemental Information |
|---|
| Specifications |
|---|
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 219330-10MG | 04055977202090 |
Documentation
β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem FDS
| Titre |
|---|
β-Catenin/Tcf Inhibitor, FH535 - CAS 108409-83-2 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
|---|---|
| 219330 |
Références bibliographiques
| Aperçu de la référence bibliographique |
|---|
| Handeli, S., and Simon, J.A. 2008. Mol. Cancer Ther. 7, 521. |