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203391 (-)-Blebbistatin - CAS 856925-71-8 - Calbiochem

The active enantiomer of (±)-Blebbistatin that accounts for the inhibitory activity towards ATPase and myosin II-dependent cellular processes.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: ATPase
203391
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
856925-71-8C₁₈H₁₆N₂O₂

Products

RéférenceConditionnement Qté
203391-1MG Ampoule plast. 1 mg
Description
OverviewThe active enantiomer of (±)-Blebbistatin (Cat. No. 203390) that accounts for the inhibitory activity towards ATPase (IC50 = ~2 µM) and myosin II-dependent cellular processes. Also reported to potently inhibit the actomyosin ATPase activities of expressed smooth muscle myosin IIA (SMA) and smooth muscle myosin IIB (SMB) smooth muscle myosin II heavy-chain isoforms (IC50 ~3 µM).
Catalogue Number203391
Brand Family Calbiochem®
References
ReferencesEddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther. 320, 865.
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
Straight, A.F., et al. 2003. Science 299, 1743.
Product Information
CAS number856925-71-8
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₈H₁₆N₂O₂
Chemical formulaC₁₈H₁₆N₂O₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetATPase
Primary Target IC<sub>50</sub>2 µM
Purity≥98% by Chiral HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Harmful & Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month in 90% DMSO or methanol (-20°C). Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
203391-1MG 04055977221275

Documentation

(-)-Blebbistatin - CAS 856925-71-8 - Calbiochem FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

(-)-Blebbistatin - CAS 856925-71-8 - Calbiochem Certificats d'analyse

TitreNuméro de lot
203391

Références bibliographiques

Aperçu de la référence bibliographique
Eddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther. 320, 865.
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
Straight, A.F., et al. 2003. Science 299, 1743.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2011 RFH
DescriptionThe active enantiomer of (±)-Blebbistatin (Cat. No. 203390) that accounts for the inhibitory activity toward ATPase (IC50 ~2 µM) and myosin II-dependent cellular processes. Also reported to potently inhibit the actomyosin ATPase activities of expressed smooth muscle myosin IIA (SMA) and smooth muscle myosin IIB (SMB) smooth muscle myosin II heavy-chain isoforms (IC50 ~3 µM).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number856925-71-8
Chemical formulaC₁₈H₁₆N₂O₂
Structure formulaStructure formula
Purity≥98% by Chiral HPLC
Solubility100% DMSO (100 mg/ml), 90% DMSO (75 mg/ml) or Methanol (1.5 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month in 90% DMSO or methanol (-20°C). Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
Toxicity Harmful & Carcinogenic / Teratogenic
ReferencesEddinger, T.J. et al. 2007. J. Pharmacol. Exp. Ther. 320, 865.
Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
Straight, A.F., et al. 2003. Science 299, 1743.