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121974 ω-Agatoxin IVA, Agelenopsis aperta

ω-Agatoxin IVA, Agelenopsis aperta : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: ω-Aga-IVA

121974
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Aperçu

Replacement Information

Products

RéférenceConditionnement Qté
US1121974-5UG Ampoule plast. 5 μg
Description
OverviewPotent selective high affinity blocker of P-type Ca2+ channels (Kd = 2 nM). Reported to abolish nicotine-evoked responses in cardiac vagal neurons (˜100 nM).
Catalogue Number121974
Brand Family Calbiochem®
Synonymsω-Aga-IVA
References
ReferencesWang, J., et al. 2001. J. Neurophysiol. 85, 164.
Nooney, J.M., and Lodge, D. 1996. Eur. J. Pharmacol. 306, 41.
Mintz, I.M., et al. 1992. Nature 355, 827.
Turner, T.J., et al. 1992. Science 258, 310.
Product Information
CAS number145017-83-0
FormWhite powder
Hill FormulaC₂₂₂H₃₇₁N₆₉O₆₁S₁₁
Chemical formulaC₂₂₂H₃₇₁N₆₉O₆₁S₁₁
Quality LevelMQ100
Applications
Biological Information
Biological activityPotently inhibits the Cav2.1 channel currents expressed in HEK293 cells.
Purity≥99% by HPLC
Physicochemical Information
Peptide SequenceH-Met-Lys-Lys-Lys-Cys⁵-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys¹³-Lys-Trp-Gly-Gly-Thr-Pro-Cys²⁰-Cys²¹-Arg-Gly-Arg-Gly-Cys²⁶-Ile-Cys²⁸-Ser-Ile-Met-Gly-Thr-Asn-Cys³⁵-Glu-Cys³⁷-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH (disulfide bonds: 5 → 21; 13 → 26; 20 → 37; 28 → 35)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Référence GTIN
US1121974-5UG 04053252040801

Documentation

ω-Agatoxin IVA, Agelenopsis aperta FDS

Titre

Fiche de données de sécurité des matériaux (FDS) 

Références bibliographiques

Aperçu de la référence bibliographique
Wang, J., et al. 2001. J. Neurophysiol. 85, 164.
Nooney, J.M., and Lodge, D. 1996. Eur. J. Pharmacol. 306, 41.
Mintz, I.M., et al. 1992. Nature 355, 827.
Turner, T.J., et al. 1992. Science 258, 310.
Fiche technique

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-May-2011 RB
Synonymsω-Aga-IVA
DescriptionA potent and selective blocker of the P-type voltage-dependent Ca2+ channels (Kd = 2 nM).
FormWhite powder
CAS number145017-83-0
Chemical formulaC₂₂₂H₃₇₁N₆₉O₆₁S₁₁
Peptide SequenceH-Met-Lys-Lys-Lys-Cys⁵-Ile-Ala-Lys-Asp-Tyr-Gly-Arg-Cys¹³-Lys-Trp-Gly-Gly-Thr-Pro-Cys²⁰-Cys²¹-Arg-Gly-Arg-Gly-Cys²⁶-Ile-Cys²⁸-Ser-Ile-Met-Gly-Thr-Asn-Cys³⁵-Glu-Cys³⁷-Lys-Pro-Arg-Leu-Ile-Met-Glu-Gly-Leu-Gly-Leu-Ala-OH (disulfide bonds: 5 → 21; 13 → 26; 20 → 37; 28 → 35)
Purity≥99% by HPLC
Biological activityPotently inhibits the Cav2.1 channel currents expressed in HEK293 cells.
SolubilityH₂O (1 mg/ml) or Saline (1 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and refrigerate (4°C) for short-term storage or freeze (-20°C) for long-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 3 months at -20°C.
Toxicity Harmful
ReferencesWang, J., et al. 2001. J. Neurophysiol. 85, 164.
Nooney, J.M., and Lodge, D. 1996. Eur. J. Pharmacol. 306, 41.
Mintz, I.M., et al. 1992. Nature 355, 827.
Turner, T.J., et al. 1992. Science 258, 310.