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586005 Thapsigargin - CAS 67526-95-8 - Calbiochem

586005
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Overview

Key Spec Table

CAS #Empirical Formula
67526-95-8C₃₄H₅₀O₁₂

Products

Catalogue NumberPackaging Qty/Pack
586005-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable tumor-promoting sesquiterpene lactone that releases Ca2+ by inhibiting endoplasmic reticular Ca2+-ATPase (IC50 = 4-13 nM). Does not increase inositol phosphates and has no significant effect on protein kinase C. Increases Ca2+-dependent Na+ influx in human platelets in a dose-dependent manner. Induces apoptosis in rat thymocytes and in human hepatoma cells. Shown to induce apoptosis in alveolar rhabdomyosarcoma cells by elevating Akt-stimulated PAX3-FOXO1 phosphorylation and promoting its proteasomal degradation.
Catalogue Number586005
Brand Family Calbiochem®
References
ReferencesJothi, M., et al. 2013. Mol. Cancer Ther. In press.
Won, J.G. and Orth, D.N. 1995. Endocrinology 136, 5399.
Tepel, M., et al. 1994. Biochim. Biophys. Acta 1220, 248.
Begum, N., et al. 1993. J. Biol. Chem. 268, 3352.
Low, A.M., et al. 1993. Eur. J. Pharmacol. 230, 53.
Tsukamoto, A. and Karneko, Y. 1993. Cell. Biol. Int. 17, 969.
Wong, W.L., et al. 1993. Biochem. J. 289, 71.
Glennon, M.C., et al. 1992. J. Biol. Chem. 267, 25568.
Xu, Y., et al. 1992. J. Neurochem. 59, 2224.
Mason, M.J., et al. 1991. J. Biol. Chem. 266, 20856.
Thastrup, O., et al. 1990. Proc. Natl. Acad. Sci. USA 87, 2466.
Product Information
CAS number67526-95-8
ATP CompetitiveN
FormColorless solid
Hill FormulaC₃₄H₅₀O₁₂
Chemical formulaC₃₄H₅₀O₁₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Biological Information
Primary Targetendoplasmic reticular Ca2+ ATPase
Primary Target IC<sub>50</sub>4-13 nM against endoplasmic reticular Ca2+-ATPase
Purity≥97% by TLC
Physicochemical Information
Cell permeableY
Safety Information
R PhraseR: 36/37/38-42

Irritating to eyes, respiratory system and skin.
May cause sensitization by inhalation.
S PhraseS: 36/37/39-26

Wear suitable protective clothing, gloves and eye/face protection.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 2-3 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
586005-1MG 04055977265026