Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

579052 TAPI-2 - CAS 187034-31-7 - Calbiochem

TAPI-2, CAS 187034-31-7, is a hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes.

TAPI-2 - CAS 187034-31-7 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: N-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-2

Primary Target: MMPs
579052
Purchase on Sigma-Aldrich

Overview

Key Spec Table

CAS #Empirical Formula
187034-31-7C₁₉H₃₇N₅O₅

Products

Catalogue NumberPackaging Qty/Pack
579052-1MG Plastic ampoule 1 mg
Add To Favorites
Description
OverviewA hydroxamate-based inhibitor of MMPs and TACE. Inhibits the activation-induced shedding of L-selectin from neutrophils, eosinophils, and lymphocytes, as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM). Also available as a 10 mM solution in H2O (Cat. No. 509612).
Catalogue Number579052
Brand Family Calbiochem®
SynonymsN-(R)-[2-(Hydroxyaminocarbonyl)methyl]-4-methylpentanoyl-L-t-butyl-alanyl-L-alanine, 2-aminoethyl Amide, TNF-α Protease Inhibitor-2
References
ReferencesBennett, T.A., et al. 2000. J. Immunol. 164, 4120.
Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
Parvathy, S., et al. 1997. Biochem. J. 327, 37.
Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
Product Information
CAS number187034-31-7
ATP CompetitiveN
DeclarationManufactured exclusively by Peptides International, Louisville, Kentucky, USA.
FormWhite solid
Hill FormulaC₁₉H₃₇N₅O₅
Chemical formulaC₁₉H₃₇N₅O₅
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetMMPs
Primary Target IC<sub>50</sub>18 µM against angiotensin converting enzyme
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
579052-1MG 04055977265378