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574714 Syk Inhibitor IV, BAY 61-3606 - CAS 732983-37-8 - Calbiochem

Syk Inhibitor IV, BAY 61-3606, CAS 732938-37-8, is a cell-permeable, potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606

Primary Target: Syk
574714
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Overview

Key Spec Table

CAS #Empirical Formula
732983-37-8C₂₀H₁₈N₆O₃ • HCl • H₂O

Products

Catalogue NumberPackaging Qty/Pack
574714-2MG Glass bottle 2 mg
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Description
OverviewA cell-permeable imidazopyrimidine compound that acts a potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM) with no inhibitory effect against Btk, Fyn, Itk, Lyn, and Src even at concentrations as high as 4.7 µM. Shown to inhibit Syk-mediated cellular functions in vitro and exhibit good oral bioavailability and in vivo effacacy in the treatment of various allgery and asthma conditions in rat models.
Catalogue Number574714
Brand Family Calbiochem®
Synonyms2-(7-(3,4-Dimethoxyphenyl)-imidazo[1,2-c]pyrimidin-5-ylamino)-nicotinamide, HCl, BAY 61-3606
References
ReferencesYamamoto, N., et al. 2003. J. Pharm. Exp. Ther. 306, 1174.
Product Information
CAS number732983-37-8
ATP CompetitiveY
FormYellow solid
Hill FormulaC₂₀H₁₈N₆O₃ • HCl • H₂O
Chemical formulaC₂₀H₁₈N₆O₃ • HCl • H₂O
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSyk Inhibitor IV, BAY 61-3606, CAS 732938-37-8, is a cell-permeable, potent, ATP-competitive, reversible, and highly selective inhibitor of Syk tyrosine kinase activity (IC50 = 10 nM).
Biological Information
Primary TargetSyk
Primary Target IC<sub>50</sub>10 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
574714-2MG 04055977189698