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573108 STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem

STAT5 Inhibitor, CAS 285986-31-4, is a cell-permeable compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Nʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide

573108
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
285986-31-4C₁₆H₁₁N₃O₃

Products

Catalogue NumberPackaging Qty/Pack
573108-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50 >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.
Catalogue Number573108
Brand Family Calbiochem®
SynonymsNʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
References
ReferencesMuller, J., et al. 2008. ChemBioChem 9, 723.
Product Information
CAS number285986-31-4
FormWhite solid
Hill FormulaC₁₆H₁₁N₃O₃
Chemical formulaC₁₆H₁₁N₃O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationSTAT5 Inhibitor, CAS 285986-31-4, is a cell-permeable compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity).
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
573108-10MG 04055977265941

Documentation

STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

STAT5 Inhibitor - CAS 285986-31-4 - Calbiochem Certificates of Analysis

TitleLot Number
573108

References

Reference overview
Muller, J., et al. 2008. ChemBioChem 9, 723.

Brochure

Title
An Introduction to Inhibitors and Their Biological Applications - 1st Edition

Technical Info

Title
JAK/STAT Signaling Research Focus
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision09-May-2011 RFH
SynonymsNʹ-((4-Oxo-4H-chromen-3-yl)methylene)nicotinohydrazide
DescriptionA cell-permeable nonpeptidic nicotinoyl hydrazone compound that selectively targets the SH2 domain of STAT5 (IC50 = 47 µM against STAT5b SH2 domain EPO peptide binding activity), while exhibiting much less effect towards the SH2 domain of STAT1, STAT3, or Lck (IC50 >500 µM). Shown to block STAT5/STAT5 DNA binding activity in K562 nuclear extract and inhibit IFN-α-stimulated STAT5, but not STAT1 or STAT3, tyrosine phosphorylation in Daudi cells.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number285986-31-4
Chemical formulaC₁₆H₁₁N₃O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (25 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesMuller, J., et al. 2008. ChemBioChem 9, 723.