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559408 SB 220025, Trihydrochloride - CAS 197446-75-6 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV

559408
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
US1559408-500UG Plastic ampoule 500 μg
Description
OverviewA cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.
Catalogue Number559408
Brand Family Calbiochem®
Synonyms5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
References
ReferencesJackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
Wang, Z., et al. 1998. Structure 6, 1117.
Product Information
CAS number197446-75-6
FormWhite solid
Hill FormulaC₁₈H₁₉FN₆ • 3HCl
Chemical formulaC₁₈H₁₉FN₆ • 3HCl
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
US1559408-500UG 04053252043314

Documentation

SB 220025, Trihydrochloride - CAS 197446-75-6 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Jackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
Wang, Z., et al. 1998. Structure 6, 1117.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-September-2014 JSW
Synonyms5-(2-Amino-4-pyrimidinyl)-4-(4-fluorophenyl)-1-(4-piperidinlyl)imidazole, p38 MAP Kinase Inhibitor XIV
DescriptionA cell-permeable, potent, reversible, ATP-competitive, and specific inhibitor of human p38 MAP Kinase (IC50 = 60 nM). Binds to an extended pocket in the active site of the enzyme. Exhibits over 2000-fold greater selectivity for p38 MAPK over ERK (p42/p44 MAP kinase), 500-fold over PKA, 50-fold over PKC, and >1000-fold over EGFR. Also acts as a potent inhibitor of angiogenesis and as an inhibitor of LPS-induced TNF-α production.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number197446-75-6
Chemical formulaC₁₈H₁₉FN₆ • 3HCl
Purity≥98% by HPLC
SolubilityH₂O (22 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesJackson, J.R., et al. 1998. J. Pharmacol. Exp. Ther. 284, 687.
Wang, Z., et al. 1998. Structure 6, 1117.