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416154 Pre-mRNA Splicing Inhibitor, Isoginkgetin - CAS 548-19-6 - Calbiochem

Pre-mRNA Splicing Inhibitor, Isoginkgetin, CAS 548-19-6, is a cell-permeable inhibitor of pre-mRNA splicing. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one

416154
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Overview

Key Spec Table

CAS #Empirical Formula
548-19-6C₃₂H₂₂O₁₀

Products

Catalogue NumberPackaging Qty/Pack
416154-10MG Glass bottle 10 mg
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Description
OverviewA cell-permeable, naturally isolated Ginkgo biloba biflavanoid that acts as a general pre-mRNA splicing inhibitor (ICmax = 50 µM in splicing assays using HeLa nuclear extract) by blocking the spliceosome-meidated splicing process at the prespliceosome/A complex stage. Isoginkgetin treatment is shown to result in growth arrest in HEK293-derived cultures in a reversible manner without affecting cell viability (33 µM for 24 h).
Catalogue Number416154
Brand Family Calbiochem®
Synonyms8-(5-(5,7-Dihydroxy-4-oxo-4H-chromen-2-yl)-2-methoxyphenyl)-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
References
ReferencesKim, H.Y., et al. 2008. Arch. Pharm. Res. 31, 265.
O'Brien, K., et al. 2008. J. Biol. Chem. 283, 33147.
Yoon, S,O., et al. 2006. Mol. Cancer Ther. 5, 2666.
Product Information
CAS number548-19-6
FormYellow solid
Hill FormulaC₃₂H₂₂O₁₀
Chemical formulaC₃₂H₂₂O₁₀
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationPre-mRNA Splicing Inhibitor, Isoginkgetin, CAS 548-19-6, is a cell-permeable inhibitor of pre-mRNA splicing. Blocks spliceosome-mediated splicing process at the pre-spliceosome/A complex stage.
Biological Information
Purity≥98% by HPLC
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
416154-10MG 04055977187786