506154 Sigma-AldrichPifithrin-α, p-Nitro, Cyclic - CAS 60477-38-5 - Calbiochem
A cell-permeable p53 inhibitor that exhibits 10-fold higher potency and 50% longer half-life than Pifithrin-α.
More>> A cell-permeable p53 inhibitor that exhibits 10-fold higher potency and 50% longer half-life than Pifithrin-α. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-(4-Nitrophenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 60477-38-5 | C₁₅H₁₃N₃O₂S |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 506154-5MG | Plastic ampoule | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable p53 inhibitor that exhibits 10-fold higher potency (ED50 = 30 nM in protecting etoposide-induced cortical neuron death) and 50% longer half-life (t1/2 = 6h in neuron culture medium at 37°C) than Pifithrin-α (Cat. No. 506132). However, despite its in vitro efficacy, this inhibitor is not effective when adminstered in rats in vivo. For in vivo applications, please consider Pifithrin-α, p-Nitro (Cat. No. 506152). |
| Catalogue Number | 506154 |
| Brand Family | Calbiochem® |
| Synonyms | 2-(4-Nitrophenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole |
| References | |
|---|---|
| References | Pietrancosta, N., et al. 2006. J. Med. Chem. 49, 3645. |
| Product Information | |
|---|---|
| CAS number | 60477-38-5 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₁₅H₁₃N₃O₂S |
| Chemical formula | C₁₅H₁₃N₃O₂S |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | p53 |
| Primary Target IC<sub>50</sub> | ED50 = 30 nM in protecting etoposide-induced cortical neuron death |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 506154-5MG | 04055977272246 |