481412 Sigma-AldrichNF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem
The NF-kB Activation Inhibitor IV, also referenced under CAS 139141-12-1, controls the biological activity of NF-kB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
More>> The NF-kB Activation Inhibitor IV, also referenced under CAS 139141-12-1, controls the biological activity of NF-kB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (E)-2-Fluoro-4ʹ-methoxystilbene
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Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 139141-12-1 | C₁₅H₁₃FO |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 481412-10MG | Plastic ampoule | 10 mg |
| Description | |
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| Overview | A cell-permeable trans-stilbene Resveratrol (Cat. No. 554325) analog that exhibits much enhanced anti-inflammatory potency, but no anti-oxidant activity. Suppresses LPS-induced COX-2 mRNA expression in BV-2 cells (~46% inhibition at 150 nM) and Shown to be ~130-fold more potent than Resveratrol in inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells (IC50 = 150 nM). |
| Catalogue Number | 481412 |
| Brand Family | Calbiochem® |
| Synonyms | (E)-2-Fluoro-4ʹ-methoxystilbene |
| References | |
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| References | Heynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182. |
| Product Information | |
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| CAS number | 139141-12-1 |
| ATP Competitive | N |
| Form | Crystalline solid |
| Hill Formula | C₁₅H₁₃FO |
| Chemical formula | C₁₅H₁₃FO |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | NF-κB Activation |
| Primary Target IC<sub>50</sub> | 150 nM inhibiting TNF-α-stimulated NF-κB reporter activity in 293T cells. |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 481412-10MG | 04055977183726 |
Documentation
NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem SDS
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NF-kB Activation Inhibitor IV - CAS 139141-12-1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 481412 |
References
| Reference overview |
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| Heynekamp, J.J., et al. 2006. J. Med. Chem. 49, 7182. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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