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FCMAB194F Milli-Mark™ Anti-CD38-FITC Antibody, clone AT13/5

Milli-Mark Anti-CD38-FITC Antibody, clone AT13/5 is an antibody against CD38 for use in FC.

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Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology UniProt Number: P28907
FCMAB194F
100 tests  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCMFITCMonoclonal Antibody
Description
Catalogue NumberFCMAB194F
Trade Name
  • Milli-Mark
DescriptionMilli-Mark™ Anti-CD38-FITC Antibody, clone AT13/5
Alternate Names
  • ADP-ribosyl cyclase 1
  • Cyclic ADP-ribose hydrolase 1
  • cADPr hydrolase 1
  • T10
Background InformationCD38 is a 45 kDa type II integral membrane glycoprotein consisting of an N-terminal 20 amino acid cytoplasmic domain, a 23 amino acid transmembrane domain, and a 257 amino acid extracellular domain. CD38 is associated with different molecules in different cell types and these unique combinations cause unique cell-type specific signaling. One of the known ligands that activates CD38-mediated signaling is CD31 (Deaglio, 2001). CD38 is expressed by a number of different cell types and the pattern of expression often changes with differentiation and maturation. Thus, CD38 expression is found during early stages of B and T-cell differentiation, is lacking during the later intermediate stages, and is regained near the end of maturation. CD38 is expressed at variable levels on the majority of hematopoietic cells, prevalently during early differentiation and activation, and it is expressed strongly on plasma cells (Jackson, 1990; Terstappen, 1990; Morra, 1997). CD38-postive cell types outside the hematopoietic system include subsets from the gut, brain, prostate, pancreas, bone, eye, and muscle (Deaglio, 2001). CD38 is expressed on approximately 60% of CD34-positive peripheral blood mononuclear cells. The least mature CD34-postive cells are characterized by a lack of CD38 (Herbein, 1994).
Anti-CD38, AT13/5 was included in the Sixth International Workshop and Conference on Human Leucocyte Differentiation Antigens, and studies by a number of laboratories confirmed its reactivity with CD38 (Morra, 1997).
Product Information
FormatFITC
Control
  • Human Lymphocytes
PresentationPurified Mouse monoclonal IgG1 conjugated to FITC in 0.05M Tris-HCl buffer with 1% BSA, Sodium Azide at 0.097% at pH 7.2.
Quality LevelMQ100
Applications
ApplicationMilli-Mark Anti-CD38-FITC Antibody, clone AT13/5 is an antibody against CD38 for use in FC.
Key Applications
  • Flow Cytometry
Biological Information
ImmunogenNamalwa cells (B lymphocyte cell line from Burkitt's lymphoma)
CloneAT13/5
HostMouse
SpecificityAntibody recognizes Human CD38 antigen.
IsotypeIgG1κ
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryCD38 is a novel multifunctional ectoenzyme widely expressed in cells and tissues especially in leukocytes. CD38 also functions in cell adhesion,signal transduction and calcium signaling.
Purification MethodProtein A Purfied
UniProt Number
UniProt SummarySynthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system. Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma. Preferentially expressed at both early and late stages of the B and T-cell maturation. It is also detected on erythroid and myeloid progenitors in bone marrow, where the level of surface expression was shown to decrease during differentiation of blast-forming unit E to colony-forming unit E.
Molecular Weight 45 kDa (Deaglio, 2001)
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using human lymphocytes
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8°C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 tests
Global Trade Item Number
Catalogue Number GTIN
FCMAB194F 04053252480324