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FCMAB135F Milli-Mark Anti-BMP-7-FITC Antibody, clone 2A10

Detect BMP-7 using this Milli-Mark Anti-BMP-7-FITC Antibody, clone 2A10 validated for use in FC.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Stem Cell Research Research Sub-Category: Mesenchymal Stem Cells Gene Symbol: BMP7, OP1 UniProt Number: P18075
FCMAB135F
100 tests  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HFCMFITCMonoclonal Antibody
Description
Catalogue NumberFCMAB135F
Trade Name
  • Milli-Mark
DescriptionMilli-Mark Anti-BMP-7-FITC Antibody, clone 2A10
Alternate Names
  • Bone morphogenetic protein-7
  • osteogenic protein-1
Background InformationBone morphogenetic protein-7 (BMP-7), also known as osteogenic protein-1, is a member of the TGF- superfamily, and is widely expressed during embryonic development. Like other members of the bone morphogenetic protein family, BMP-7 works synergistically with BMP-2 to play a key role in the differentiation of mesenchymal cells into bone and cartilage tissues by actively recruiting stem cells from the surrounding tissue, thereby initiating the bone formation cascade. In adult cells, BMP-7 is predominately expressed in the brain, kidneys, and bladder.
Product Information
FormatFITC
Control
  • HeLa cells.
PresentationPurified mouse monoclonal IgG1κ conjugated to FITC in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationDetect BMP-7 using this Milli-Mark Anti-BMP-7-FITC Antibody, clone 2A10 validated for use in FC.
Key Applications
  • Flow Cytometry
Working Solution Cells / test Total Reaction Volume
5 μl 5 x 105 Cells / 95 μl PBS 100 μl
10 μl 1 x 106 Cells / 90 μl PBS 100 μl
Biological Information
Immunogen Recombinant full-length BMP-7 protein.
EpitopeUnknown
Clone2A10
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostMouse
SpecificityThis monoclonal antibody recognizes BMP-7.
IsotypeIgG1κ
Species Reactivity
  • Human
Species Reactivity NoteTested and passed on Human. Unconjugated antibody (MAB4350) also reacts against Mouse.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • BMP7
  • OP1
Purification MethodProtein G Purified
UniProt Number
UniProt SummaryFunction Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.

Subunit structure Homodimer; disulfide-linked. Interacts with SOSTDC1. Interacts with TWSG1 By similarity.

Subcellular location Secreted.

Tissue specificity Expressed in the kidneys and bladder. Lower levels seen in the brain.

Post-translational modification Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (Ref.5).

Pharmaceutical use Available under the names Osigraft (Stryker). Its use is indicated in the treatment of tibial non-union of at least 9 month duration, secondary to trauma, in skeletally mature patients, in cases where autograft has failed or is unfeasible.

Sequence similarities Belongs to the TGF-beta family.
Molecular Weight 46kDa Observed
Product Usage Statements
Quality AssuranceEvaluated by flow cytometry using HeLa cells.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 tests
Global Trade Item Number
Catalogue Number GTIN
FCMAB135F 04053252699931