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475863 MK2a Inhibitor - CAS 41179-33-3 - Calbiochem

475863
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
41179-33-3C₂₂H₂₀FNO₂

Products

Catalogue NumberPackaging Qty/Pack
475863-5MG Plastic ampoule 5 mg
Description
OverviewA reversible p-amidophenolic compound that selectively inhibits the phosphorylation of MK2a (mitogen-activated protein kinase-activated protein kinase 2a; Kiapp = 330 nM) by p38α in a non-ATP-competitive manner. Does not block the kinase activity of p38α towards the other two known p38 substrates, MBP and ATF-2.
Catalogue Number475863
Brand Family Calbiochem®
SynonymsMAPKAPK2a Inhibitor, Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor, 4-(2ʹ-Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide, CMPD1
References
ReferencesDavidson, W., et al. 2004. Biochemistry 43, 11658.
Lukas, S.M., et al. 2004. Biochemistry 43, 9950.
Product Information
CAS number41179-33-3
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₂₂H₂₀FNO₂
Chemical formulaC₂₂H₂₀FNO₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMk2α
Primary Target K<sub>i</sub>Kiapp = 330 nM against mitogen-activated protein kinase-activated protein kinase 2a (MK2a)
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
475863-5MG 04055977203394

Documentation

MK2a Inhibitor - CAS 41179-33-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

MK2a Inhibitor - CAS 41179-33-3 - Calbiochem Certificates of Analysis

TitleLot Number
475863

References

Reference overview
Davidson, W., et al. 2004. Biochemistry 43, 11658.
Lukas, S.M., et al. 2004. Biochemistry 43, 9950.

Posters

Title
Human Kinome & InhibitorSelect™ Libraries
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-January-2010 RFH
SynonymsMAPKAPK2a Inhibitor, Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor, 4-(2ʹ-Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide, CMPD1
DescriptionA non-ATP-competitive, reversible, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (Kiapp = 330 nM). Does not inhibit p38α-mediated phosphorylation of the the other two known p38 substrates, MBP and ATF-2.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number41179-33-3
Chemical formulaC₂₂H₂₀FNO₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml) or Ethanol (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesDavidson, W., et al. 2004. Biochemistry 43, 11658.
Lukas, S.M., et al. 2004. Biochemistry 43, 9950.