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508438 Lamellipodial Growth Promoter, C8N6 BPA Polyamine - CAS 870087-09-5 - Calbiochem

A cell-permeable, fast acting, branched polyamine. Induces growth of actin-enriched lamellipodia within minutes without the need for serum cofactors .

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Actin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine

508438
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
870087-09-5C₂₀H₄₈N₆·6HCl

Products

Catalogue NumberPackaging Qty/Pack
5084380001 Glass bottle 10 mg
Description
OverviewA cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations.

Please note that the molecular weight for this compound is batch-specific due to variable water content.
Catalogue Number508438
Brand Family Calbiochem®
SynonymsActin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine
References
ReferencesNedeva, I., et al. 2013. Nat. Commun. 4, 2165.
Product Information
CAS number870087-09-5
FormOff-white solid
Hill FormulaC₂₀H₄₈N₆·6HCl
Chemical formulaC₂₀H₄₈N₆·6HCl
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by NMR
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5084380001 04055977261974

Documentation

Lamellipodial Growth Promoter, C8N6 BPA Polyamine - CAS 870087-09-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Nedeva, I., et al. 2013. Nat. Commun. 4, 2165.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision08-July-2024 JSW
SynonymsActin Regulator, C8N6 BPA polyamine, Lamellipodial Enhancer, C8N6 BPA polyamine
DescriptionA cell-permeable, fast acting, branched polyamine (C8N6) that specifically induces the growth of actin-enriched lamellipodia within minutes (at ~ 10-100 µM) without the need for serum cofactors . Its effects are more pronounced on the edges of cells that exhibit lamellipodial activity before any treatment. Enhances nucleation by capping protein and thereby facilitates the initiation of filament branching at the lamellipodium tip. Does not affect actin polymerization in cells pre-treated with depolymerizing agents. Does not affect the survival or death of tumor cells even at higher concentration (1 mM). The assembly of actin appears to be more distinct at physiological ionic concentrations. The Cy3 conjugated version is also available (Cat. No. xxxx?)
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number870087-09-5
Chemical formulaC₂₀H₄₈N₆·6HCl
Purity≥95% by NMR
SolubilityDMSO (50 mg/ml) or H₂O (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesNedeva, I., et al. 2013. Nat. Commun. 4, 2165.