616464 Sigma-AldrichInSolution™ TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem
InSolution™ TGF-β RI Kinase Inhibitor VI, SB431542, CAS 301836-41-9, is a 100 mM solution in DMSO.A cell-permeable, selective inhibitor of SMAD2 phosphorylation (greater than 90% inhibition at 10 µM).
More>> InSolution™ TGF-β RI Kinase Inhibitor VI, SB431542, CAS 301836-41-9, is a 100 mM solution in DMSO.A cell-permeable, selective inhibitor of SMAD2 phosphorylation (greater than 90% inhibition at 10 µM). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 301836-41-9 | C₂₂H₁₆N₄O₃ • 2H₂O |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 616464-5MG | Glass bottle | 5 mg |
| Description | |
|---|---|
| Overview | A cell-permeable triarylimidazole compound that is shown to effectively inhibit cellular Smad2 phosphorylation (>90% inhibition by 10 µM inhibitor) upon vector-mediated expression of constitutively active ALK4, ALK5, or ALK7 in NIH 3T3 cells, while exhibiting little effect against Smad1 phosphorylation by other members of type I receptors for TGF-β in NIH 3T3 cultures expressing active ALK1, 2, 3, or 6. When tested directly in cell-free kinase assays, SB431542 is demonstrated to potently inhibit the activity of ALK4 and ALK5 (IC50 = 140 nM and 94 nM, respectively) with no or much reduced potency toward a panel of 24 other kinases (IC50 ≥10 µM in the presence of 10 µM ATP), including ALK2 and ALK6. Reported to improve the efficiency of 4-TF-induced human iPSCs generation from fibroblast cultures by >200-fold when used together with PD0325901 (Cat. No. 444966) and Thiazovivin (Cat. No. 420220). The solid form of this compound (Cat. No. 616461) is also available. |
| Catalogue Number | 616464 |
| Brand Family | Calbiochem® |
| Product Information | |
|---|---|
| CAS number | 301836-41-9 |
| Form | Liquid |
| Formulation | A 100 mM (5 mg/119 µl) solution of SB431542 (Cat. No. 616461) in DMSO. |
| Hill Formula | C₂₂H₁₆N₄O₃ • 2H₂O |
| Chemical formula | C₂₂H₁₆N₄O₃ • 2H₂O |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥97% by HPLC |
| Safety Information | |
|---|---|
| R Phrase | R: 36/38 Irritating to eyes and skin. |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 616464-5MG | 04055977185942 |