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509612 InSolution™ TAPI-2 - CAS 187034-31-7 - Calbiochem

A 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 in H₂O.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
509612
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
187034-31-7C₁₉H₃₇N₅O₅

Products

Catalogue NumberPackaging Qty/Pack
5096120001 Glass bottle 1 mg
Description
Catalogue Number509612
Brand Family Calbiochem®
References
ReferencesBennett, T.A., et al. 2000. J. Immunol. 164, 4120.
Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
Parvathy, S., et al. 1997. Biochem. J. 327, 37.
Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
Product Information
CAS number187034-31-7
FormLiquid
FormulationA 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 (Cat. No. 579052) in H₂O.
Hill FormulaC₁₉H₃₇N₅O₅
Chemical formulaC₁₉H₃₇N₅O₅
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
5096120001 04055977240986

Documentation

InSolution™ TAPI-2 - CAS 187034-31-7 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

References

Reference overview
Bennett, T.A., et al. 2000. J. Immunol. 164, 4120.
Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
Parvathy, S., et al. 1997. Biochem. J. 327, 37.
Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-April-2014 JSW
DescriptionA hydroxamate-based inhibitor of matrix metalloproteinases and TACE (TNF-α convertase; ADAM17). Inhibits the activation-dependent shedding of L-selectin from neutrophils, eosinophils, and lymphocytes as well as phenylarsine oxide (PAO)-induced shedding in neutrophils. Also blocks the shedding of several cell surface proteins such as pro-TGF-α, IL-6 receptor α-subunit, and β-amyloid precursor protein. Reported to inhibit TNF-α release and impart protection against aspirin-induced gastric mucosal injury. Acts as a weak inhibitor of angiotensin converting enzyme (IC50 = 18 µM).
FormLiquid
FormulationA 10 mM (1 mg/241 µL) sterile-filtered solution of TAPI-2 (Cat. No. 579052) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
CAS number187034-31-7
Chemical formulaC₁₉H₃₇N₅O₅
Purity≥97% by HPLC
Storage Protect from light
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C). Aliquots are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBennett, T.A., et al. 2000. J. Immunol. 164, 4120.
Fiorucci, S., et al. 1998. Aliment. Pharmacol. Ther. 12, 1139.
Hooper, N.M., et al. 1997. Biochem. J. 321, 265.
Parvathy, S., et al. 1997. Biochem. J. 327, 37.
Arribas, J., et al. 1996. J. Biol. Chem. 271, 11376.