539571 Sigma-AldrichInSolution™ Src Inhibitor, PP1 - Calbiochem
The InSolution™ Src Inhibitor, PP1 controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The InSolution™ Src Inhibitor, PP1 controls the biological activity of Src. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<InSolution™ Src Inhibitor, PP1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Overview
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Key Spec Table
| Empirical Formula |
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| C₁₆H₁₉N₅ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
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| 539571-5MG | Glass bottle | 5 mg |
| Description | |
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| Overview | A cell-permeable pyrazolopyrimidine compound that is shown to inhibit Src family tyrosine kinases Lck, Fyn, Hck, and Src (IC50 = 5, 6, 20, and 170 nM, respectively), as well as non-Src family kinases such as CSK, RIP2, and CK1δ (IC50 = 640 nM, 26 nM, 170 nM, respectively), in in vitro kinase assays. At 1 µM, in vitro kinase activity is reduced by more than 57% for p38α, p38β, CK1δ, CSK, RIP2, and GAK, while exhibiting much lower activity against more than 60 other kinases. Kinetic studies employing Src and [poly Glu-Tyr 4:1] indicate that the inhibition is mixed competitive with respect to the substrate and non-competitive with respect to ATP. PP1 also demonstrates anti-growth properties in several B lymphoma cultures of human and murine origins (IC50 = 2.5 to 8.0 µM) and pediatric brain tumor cells (IC50 = 1.1 to 9.7 µM). 1 mg of Src Inhibitor, PP1 (Cat. No. 567809) is also available. |
| Catalogue Number | 539571 |
| Brand Family | Calbiochem® |
| Product Information | |
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| Form | Liquid |
| Formulation | A 50 mM (5 mg/355 µl) solution of Src Inhibitor, PP1 (Cat. No. 567809) in DMSO. |
| Hill Formula | C₁₆H₁₉N₅ |
| Chemical formula | C₁₆H₁₉N₅ |
| Hygroscopic | Hygroscopic |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Purity | ≥90% by HPLC |
| Physicochemical Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information | |
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| R Phrase | R: 36/38 Irritating to eyes and skin. |
| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 539571-5MG | 04055977194708 |
Documentation
InSolution™ Src Inhibitor, PP1 - Calbiochem SDS
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InSolution™ Src Inhibitor, PP1 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 539571 |
References
| Reference overview |
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| Ke, J., et.al. 2009. Mol. Cancer 8, 132. Sikkema, A.H., et al. 2009. Cancer Res. 69, 5987. Bain, J., et al. 2007. Biochem. J. 408, 297. Bain, J., et al. 2003. Biochem. J. 371, 199. Karni, R., et al. 2003. FEBS Lett. 537, 47. Hanke, J.H., et al. 1996. J. Biol. Chem. 271, 695. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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