420097 Sigma-AldrichInSolution™ JAK Inhibitor I - CAS 457081-03-7 - Calbiochem
InSolution™ JAK Inhibitor I, CAS 457081-03-7, is a 10 mM solution in DMSO. A highly potent, ATP-competitive inhibitor of JAK. (IC50 = 15, 1, 5 & 1 nM for JAK1, 2, 3 & Tyk2, respectively).
More>> InSolution™ JAK Inhibitor I, CAS 457081-03-7, is a 10 mM solution in DMSO. A highly potent, ATP-competitive inhibitor of JAK. (IC50 = 15, 1, 5 & 1 nM for JAK1, 2, 3 & Tyk2, respectively). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, P6, Pyridone 6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 457081-03-7 | C₁₈H₁₆FN₃O |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 420097-500UG | Plastic ampoule | 500 μg |
| References | |
|---|---|
| References | Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219. |
| Product Information | |
|---|---|
| CAS number | 457081-03-7 |
| ATP Competitive | Y |
| Form | Liquid |
| Formulation | A 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420099) in DMSO. |
| Hill Formula | C₁₈H₁₆FN₃O |
| Chemical formula | C₁₈H₁₆FN₃O |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 420097-500UG | 04055977187861 |