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368059 Granzyme B Substrate II, Fluorogenic - CAS 219138-02-0 - Calbiochem

A fluorogenic substrate for the detection of granzyme B and caspase-8 activity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-IETD-AFC, Caspase-8 Substrate II

368059
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Overview

Replacement Information

Products

Catalogue NumberPackaging Qty/Pack
368059-1MG Plastic ampoule 1 mg
368059-5MG Plastic ampoule 5 mg
Description
OverviewA fluorogenic substrate for the detection of granzyme B and caspase-8 activity. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore.
Catalogue Number368059
Brand Family Calbiochem®
SynonymsZ-IETD-AFC, Caspase-8 Substrate II
References
ReferencesKarahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.
Product Information
CAS number219138-02-0
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₃₇H₄₂F₃N₅O₁₃
Chemical formulaC₃₇H₄₂F₃N₅O₁₃
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetFluorogenic substrate for the detection of granzyme B and caspase-8 activity
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Emission max.
Excitation max.
Peptide SequenceZ-Ile-Glu-Thr-Asp-AFC
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
368059-1MG 07790788049621
368059-5MG 04055977192179

Documentation

Granzyme B Substrate II, Fluorogenic - CAS 219138-02-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Granzyme B Substrate II, Fluorogenic - CAS 219138-02-0 - Calbiochem Certificates of Analysis

TitleLot Number
368059

References

Reference overview
Karahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.

Brochure

Title
Caspases and other Apoptosis Related Tools Brochure
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-July-2008 RFH
SynonymsZ-IETD-AFC, Caspase-8 Substrate II
DescriptionA fluorogenic substrate for the detection of granzyme B. Reaction can be monitored visually or quantitatively by a blue to green shift in fluorescence upon cleavage of the AFC fluorophore (excitation maximum: ~400 nm; emission maximum: ~505 nm).
FormWhite lyophilized solid
CAS number219138-02-0
Chemical formulaC₃₇H₄₂F₃N₅O₁₃
Peptide SequenceZ-Ile-Glu-Thr-Asp-AFC
Purity≥97% by HPLC
SolubilityDMSO (1 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKarahashi, H., and Amano, F. 2000. Biol. Pharm. Bull. 23, 140.