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538285 Glucosylceramide Synthase Inhibitor, Genz-123346 - CAS 491833-30-8 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (1R,2R)-nonanoic acid[2-(2ʹ,3ʹ-dihydro-benzo [1, 4] dioxin-6ʹ-yl)-2-hydroxy-1-pyrrolidin-1-ylmethyl-ethyl]-amide, GL1 synthase Inhibitor, Genz-123346, Genz123346

Primary Target: glucosylceramide synthase
538285
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Overview

Key Spec Table

CAS #Empirical Formula
491833-30-8C₂₄H₃₈N₂O₄

Products

Catalogue NumberPackaging Qty/Pack
5382850001 Glass bottle 10 mg
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Description
OverviewA cell-permeable, orally bioavailable fatty acid amide derivative that acts as a highly potent and specific inhibitor of Glucosylceramide Synthase (GL1 synthase; IC50 = 14 nM for ganglioside GM1 inhibition). Does not affect the activities of other related glycosidase, such as 1-O-acylceramide synthase, a-glucosidase, and glucocerebrosidase in any significant manner. Shown to improve glucose tolerance, improve insulin sensitivity, and normalize hemoglobin A1C levels in Zucker diabetic fatty rats (75 mg/kg/day, p.o. for 6 weeks). Also acts as an inhibitor of GlcCer synthase and blocks the conversion of ceramide to GlcCer in murine models that are orthologous to human autosomal dominant polycystic kidney disease and nephronophthisis. Diminishes Akt-mTOR signaling by reducing phosphorylation of Akt and ribosomal S6 kinase in HEK293T cells without affecting their total levels.

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538285
Brand Family Calbiochem®
Synonyms(1R,2R)-nonanoic acid[2-(2ʹ,3ʹ-dihydro-benzo [1, 4] dioxin-6ʹ-yl)-2-hydroxy-1-pyrrolidin-1-ylmethyl-ethyl]-amide, GL1 synthase Inhibitor, Genz-123346, Genz123346
References
ReferencesShen, W., et al. 2014. J. Neurochem. 129, 884.
Natoli, T.A., et al. 2010. Nat. Med. 16, 788.
Zhao, H., et al. 2007. Diabetes. 56, 1210.
Product Information
CAS number491833-30-8
FormWhite to off-white solid
Hill FormulaC₂₄H₃₈N₂O₄
Chemical formulaC₂₄H₃₈N₂O₄
ReversibleY
Quality LevelMQ100
Biological Information
Primary Targetglucosylceramide synthase
Primary Target IC<sub>50</sub>14 nM for ganglioside GM1 suppression
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient, Blue Ice or Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
5382850001 04054839119569