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361551 GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem

The GSK-3 Inhibitor X, also referenced under CAS 740841-15-0, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: BIO-Acetoxime, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime

Primary Target: GSK-3α/β
361551
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
740841-15-0C₁₈H₁₂BrN₃O₃

Products

Catalogue NumberPackaging Qty/Pack
361551-1MG Plastic ampoule 1 mg
Description
OverviewAn acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50 = 2.4 µM, 4.3 µM and 63 µM, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50 ≥ 10 µM). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50 ≥ 0.1 µM) and mammalian (EC50 = 0.16 µM) reporter systems.
Catalogue Number361551
Brand Family Calbiochem®
SynonymsBIO-Acetoxime, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime
References
ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
Product Information
CAS number740841-15-0
ATP CompetitiveN
FormDark purple solid
Hill FormulaC₁₈H₁₂BrN₃O₃
Chemical formulaC₁₈H₁₂BrN₃O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetGSK-3α/β
Primary Target IC<sub>50</sub>10 nM against GSK-3α/β
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
361551-1MG 04055977214093

Documentation

GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem Certificates of Analysis

TitleLot Number
361551

References

Reference overview
Knockaert, M., et al. 2004. Oncogene 23, 4400.
Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsBIO-Acetoxime, (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime
DescriptionAn acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/cyclin A, and Cdk1/cyclin B (IC50 = 2.4 µM, 4.3 µM, and 63 µM, respectively). A weak inhibitor of Cdk4/cyclin D1 and many other non-related kinases (IC50 ≥ 10 µM). Yields BIO (Cat. No. 361550) upon hydrolysis.
FormDark purple solid
Intert gas (Yes/No) Packaged under inert gas
CAS number740841-15-0
Chemical formulaC₁₈H₁₂BrN₃O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml). Limited solubility in aqueous buffers; serial dilutions in DMSO may be required prior to dilution in buffer.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesKnockaert, M., et al. 2004. Oncogene 23, 4400.
Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
Meijer, L., et al. 2003. Chem. Biol. 10, 1255.