361551 Sigma-AldrichGSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem
The GSK-3 Inhibitor X, also referenced under CAS 740841-15-0, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The GSK-3 Inhibitor X, also referenced under CAS 740841-15-0, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime, BIO-Acetoxime
Recommended Products
Overview
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Key Spec Table
| CAS # | Empirical Formula |
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| 740841-15-0 | C₁₈H₁₂BrN₃O₃ |
Products
| Catalogue Number | Packaging | Qty/Pack | |
|---|---|---|---|
| 361551-1MG | Plastic ampoule | 1 mg |
| Description | |
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| Overview | An acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/A and Cdk1/B (IC50 = 2.4 µM, 4.3 µM and 63 µM, respectively). Weakly affects the activities of Cdk4/D1 and many other kinases (IC50 ≥ 10 µM). Also acts as an aryl hydrocarbon receptor agonist in both yeast (EC50 ≥ 0.1 µM) and mammalian (EC50 = 0.16 µM) reporter systems. |
| Catalogue Number | 361551 |
| Brand Family | Calbiochem® |
| Synonyms | (2ʹZ,3ʹE)-6-Bromoindirubin-3ʹ-acetoxime, BIO-Acetoxime |
| References | |
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| References | Knockaert, M., et al. 2004. Oncogene 23, 4400. Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935. Meijer, L., et al. 2003. Chem. Biol. 10, 1255. |
| Product Information | |
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| CAS number | 740841-15-0 |
| ATP Competitive | N |
| Form | Dark purple solid |
| Hill Formula | C₁₈H₁₂BrN₃O₃ |
| Chemical formula | C₁₈H₁₂BrN₃O₃ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | GSK-3α/β |
| Primary Target IC<sub>50</sub> | 10 nM against GSK-3α/β |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | N |
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| Materials Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 361551-1MG | 04055977214093 |
Documentation
GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem SDS
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GSK-3 Inhibitor X - CAS 740841-15-0 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 361551 |
References
| Reference overview |
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| Knockaert, M., et al. 2004. Oncogene 23, 4400. Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935. Meijer, L., et al. 2003. Chem. Biol. 10, 1255. |