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GF322 GDNF, Human Recombinant
Animal Free

GDNF, Human Recombinant
Animal Free MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
UniProt Number: P39905
GF322
10µg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

SourcePurity
Protein is expressed in E.coli.
The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.		Product endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
Description
Catalogue NumberGF322
DescriptionGDNF, Human Recombinant
Animal Free
Alternate Names
  • Glial Derived Neurotrophic Factor
Background InformationGDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRα (α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability.
The functional human GDNF ligand is a disulfide-linked homodimer, of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which (Cys 101) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
References
Product Information
PresentationProduct is presented in 10 mM Sodium Citrate + 150 mM NaCl and is filtered through a 0.2 micron filter before lyophilization.
Quality LevelMQ100
Applications
Biological Information
PurityProduct endotoxin level is <0.1 ng/μg of protein (<1 EU/μg).
SourceProtein is expressed in E.coli.
The protein is manufactured without the use of any animal products/reagents and is considered Animal-Free and can be used in protocols where possible transmisson of animal viruses and contamination must be avoided.
UniProt Number
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceThe ED50 was determined by the proliferation of rat C6 cells is ≤ 0.1 µg/ml, corresponding to a specific activity of ≥ 1 x 10^5 units/mg.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore at -20°C for up to 4 months from date of receipt Centrifuge the vial prior to opening.
Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein and store in working aliquots at -20°C.
Packaging Information
Material Size10µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
GF322 04053252979620

Documentation

GDNF, Human Recombinant
Animal Free SDS

Title

Safety Data Sheet (SDS) 

GDNF, Human Recombinant
Animal Free Certificates of Analysis

TitleLot Number
GDNF, Human Recombinant Animal Free - Q2436471 Q2436471
GDNF, Human Recombinant - 3503862 3503862
GDNF, Human Recombinant -2709054 2709054
GDNF, Human Recombinant Animal Free - 3257048 3257048
GDNF, Human Recombinant Animal Free - 3293724 3293724
GDNF, Human Recombinant Animal Free - 3410079 3410079
GDNF, Human Recombinant Animal Free - 3437315 3437315
GDNF, Human Recombinant Animal Free - 3458522 3458522
GDNF, Human Recombinant Animal Free - 3501006 3501006
GDNF, Human Recombinant Animal Free - 3524850 3524850
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