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538244 Cyclorasin 9A5 - Calbiochem

538244
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Overview

Key Spec Table

Empirical Formula
C₇₅H₁₀₈FN₂₅O₁₃

Products

Catalogue NumberPackaging Qty/Pack
5382440001 Glass bottle 5 mg
Description
OverviewA cell-permeable 11-mer cyclic peptide that displays high-affinity towards Ras-GTP (IC50 = 120 nM for K-Ras G12V) and inhibits Ras signaling. Shown to readily localize into cytoplasm and directly bind to Ras-GTP near the effector-binding site in a reversible manner. Dose-dependently impairs Ras-B-Raf interaction and blocks EGF-stimulated activation of Akt, MEK & ERK (IC50 = 3.1 µM in H1299 cells). Efficiently induces lung cancer cell growth arrest and triggers apoptosis (LD50 = 3.0 µM in H1299). NOTE: ala = D-Alanine; nal = D-2-naphthylalanine; nle = D-norleucine; Fpa = L-4-Fluorophenylalanine

Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
Catalogue Number538244
Brand Family Calbiochem®
SynonymsCyclic Ras Inhibitor
References
ReferencesUpadhyaya. P., et al. 2015. Angew. Chem. Int. Ed. 54, 7602.
Product Information
FormOff-white solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₇₅H₁₀₈FN₂₅O₁₃
Chemical formulaC₇₅H₁₀₈FN₂₅O₁₃
Hygroscopic Hygroscopic
ReversibleY
Quality LevelMQ100
Biological Information
Primary TargetRas-GTP
Primary Target IC<sub>50</sub>120 nM for K-Ras G12V
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Peptide Sequencecyclo(-Trp-Thr-ala-Arg-Arg-Arg-nal-Arg-Fpa-nle-Gln)
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
5382440001 04054839119446