217708 Sigma-AldrichCdc42/Rac1 GTPase Inhibitor, ML141 - Calbiochem
Cdc42/Rac1 GTPase Inhibitor, ML141, CAS 71203-35-5, is a cell-permeable, allosteric, potent, selective, reversible, non-competitive inhibitor of Cdc42 GTPases.
More>> Cdc42/Rac1 GTPase Inhibitor, ML141, CAS 71203-35-5, is a cell-permeable, allosteric, potent, selective, reversible, non-competitive inhibitor of Cdc42 GTPases. Less<<Synonyms: CID2950007, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl)-benzenesulfonamide, MLS00693334, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II
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Overview
Key Spec Table
CAS # | Empirical Formula |
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71203-35-5 | C₂₂H₂₁N₃O₃S |
Products
Catalogue Number | Packaging | Qty/Pack | |
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217708-25MG | Glass bottle | 25 mg |
Description | |
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Overview | A cell-permeable, allosteric, trisubstituted dihydropyrazolyl compound that acts as a potent, selective, reversible and non-competitive inhibitor of Cdc42 GTPases (IC50 = 0.2, 2.6 and 5.4 µM against nucleotide depleted Cdc42-wt, Cdc42-wt and Cdc42 activated mutant, respectively) with excellent selectivity over Rho family GTPases (IC50 > 100 µM for Ras-wt, Ras activated mutant, Rab7-wt, Rab2a-wt, Rac1-wt and Rac1 activated mutant). Shown to efficiently block Cdc42 association with GTPγS and PAK-PBD, and decrease GTP-Cdc42 (> 95%) and GTP-Rac1 (≥40%) contents in EGF-stimulated 3T3 cells, and inhibit Bradykinin (Cat. No. 05-23-0500)-induced filopodia formation in 3T3 cells at 10 µM. |
Catalogue Number | 217708 |
Brand Family | Calbiochem® |
Synonyms | CID2950007, (±)-4-(5-(4-Methoxyphenyl)-3-phenyl-4,5-dihydro-1H-pyrazol-1-yl))-benzenesulfonamide, (±)-4-(4,5-Dihydro-5-(4-methoxyphenyl)-3-phenyl-1H-pyrazol-1-yl)-benzenesulfonamide, MLS00693334, CDC42 GTPase Inhibitor II, CDC42 Inhibitor II, Rac1 Inhibitor V, Rac1 GTPase Inhibitor II |
Product Information | |
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CAS number | 71203-35-5 |
Form | Yellow-white solid |
Hill Formula | C₂₂H₂₁N₃O₃S |
Chemical formula | C₂₂H₂₁N₃O₃S |
Structure formula Image | |
Quality Level | MQ100 |
Applications | |
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Application | Cdc42/Rac1 GTPase Inhibitor, ML141, CAS 71203-35-5, is a cell-permeable, allosteric, potent, selective, reversible, non-competitive inhibitor of Cdc42 GTPases. |
Biological Information | |
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Purity | ≥99% by HPLC |
Packaging Information | |
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Packaged under inert gas | Packaged under inert gas |
Global Trade Item Number | |
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Catalogue Number | GTIN |
217708-25MG | 04055977202366 |