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627610 Caspase Inhibitor I - CAS 187389-52-2 - Calbiochem

Z-VAD-FMK, CAS 187389-52-2, is a cell-permeable, irreversible, pan-caspase inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-VAD (OMe)-FMK

Primary Target: Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells
627610
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Overview

Key Spec Table

CAS #Empirical Formula
187389-52-2C₂₂H₃₀FN₃O₇

Products

Catalogue NumberPackaging Qty/Pack
627610-1MG Plastic ampoule 1 mg
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627610-5MG Plastic ampoule 5 mg
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Description
OverviewA cell-permeable, irreversible, pan-caspase inhibitor. Inhibits Fas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells. Shown to enhance the freeze-thaw survival of human embryonic stem cells. When using with purified native or recombinant enzyme, pre-treatment with an esterase is required.
Catalogue Number627610
Brand Family Calbiochem®
SynonymsZ-VAD (OMe)-FMK
References
ReferencesHeng, B.C., et al. 2007. Biosci. Rep. 27, 257.
Martin, U., et al. 2007. Apoptosis 12, 525.
Misaghi, S., et al. 2004. Chem. Biol. 11, 1677.
Joo, C., et al. 1999. Ophthalmic Res. 31, 287.
McColl, K.S., et al. 1998. Mol. Cell. Endocrinol. 139, 229.
Thornberry, N.A. and Lazebnik, Y. 1998. Science 281, 1312.
Tolomeo, M., et al. 1998. Cell Death Differ. 5, 735.
An, S. and Know, K.A. 1996. FEBS Lett. 386, 115.
Cain, K., et al. 1996. Biochem J. 314, 27.
Mirzoeva, O.K., et al. 1996. FEBS Lett. 396, 266.
Pronk, G.J., et al. 1996. Science 271, 808.
Slee, E.A., et al. 1996. Biochem. J. 315, 21.
Chow, S.C., et al. 1995. FEBS Lett. 364, 134.
Fearnhead, H.O., et al. 1995. FEBS Lett. 375, 283.
Zhu, H., et al. 1995. FEBS Lett. 374, 303.
Product Information
CAS number187389-52-2
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₂H₃₀FN₃O₇
Chemical formulaC₂₂H₃₀FN₃O₇
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetFas-mediated apoptosis in Jurkat cells and staurosporine-induced cell death in corneal epithelial cells
PuritySingle spot by TLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Val-Ala-Asp(OMe)-CH₂F*
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 6 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
627610-1MG 04055977262810
627610-5MG 04055977262841