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218832 Caspase-3/7 Inhibitor II - CAS 775289-20-8 - Calbiochem

The Caspase-3/7 Inhibitor II, also referenced under CAS 775289-20-8, controls the biological activity of Caspase-3/7. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Ac-DNLD-CHO

Primary Target: caspase-3, caspase-7
218832
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
775289-20-8C₂₀H₃₁N₅O₁₀

Products

Catalogue NumberPackaging Qty/Pack
218832-1MG Plastic ampoule 1 mg
Description
OverviewA tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50 = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50 = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.
Catalogue Number218832
Brand Family Calbiochem®
SynonymsAc-DNLD-CHO
References
ReferencesYoshimori, A., et al. 2004. BMC Pharmacol. 4, 7.
Product Information
CAS number775289-20-8
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₀H₃₁N₅O₁₀
Chemical formulaC₂₀H₃₁N₅O₁₀
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcaspase-3, caspase-7
Primary Target IC<sub>50</sub>3.2 nM and 22.6 nM, against caspases-3 and -7, respectively
PuritySingle main spot with additional trace spot by TLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Asp-Asn-Leu-Asp-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
218832-1MG 04055977218909

Documentation

Caspase-3/7 Inhibitor II - CAS 775289-20-8 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Caspase-3/7 Inhibitor II - CAS 775289-20-8 - Calbiochem Certificates of Analysis

TitleLot Number
218832

References

Reference overview
Yoshimori, A., et al. 2004. BMC Pharmacol. 4, 7.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision31-March-2011 RFH
SynonymsAc-DNLD-CHO
DescriptionA tetrapeptidyl aldehyde that acts as a potent, reversible and active site binding inhibitor of caspases-3 and -7 (IC50 = 3.2 nM and 22.6 nM, respectively) and displays ~100-fold greater selectivity over caspases-8 and -9 (IC50 = 577.6 nM and 364.7 nM, respectively). Offers protection against Camptothecin (Cat. No. 208925), and anti-Fas-mediated apoptosis in Jurkat T cells.
Note: aldehyde-based inhibitors are less cell-permeable than FMK-based inhibitors, so higher concentrations may be required for cell-based inhibition studies (e.g. 100 µM).
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number775289-20-8
Chemical formulaC₂₀H₃₁N₅O₁₀
Peptide SequenceAc-Asp-Asn-Leu-Asp-CHO
Structure formulaStructure formula
PuritySingle main spot with additional trace spot by TLC
SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesYoshimori, A., et al. 2004. BMC Pharmacol. 4, 7.