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215911 Carbonyl Cyanide m-Chlorophenylhydrazone - CAS 555-60-2 - Calbiochem

Carbonyl Cyanide m-Chlorophenylhydrazone, CAS 555-60-2, is a protonophore uncoupling agent for oxidative phosphorylation. Shown to be about 100-fold more effective than 2, 4-DNP.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: CCCP

Primary Target: cytochrome c oxydase
215911
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Overview

Key Spec Table

CAS #
555-60-2

Products

Catalogue NumberPackaging Qty/Pack
215911-250MG Plastic ampoule 250 mg
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Description
OverviewProtonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol. Binds with cytochrome c oxidase with high affinity (Kd = 270 nM). Inhibits transport processes and depresses growth.
Catalogue Number215911
Brand Family Calbiochem®
SynonymsCCCP
References
ReferencesBona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.
Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun. 7, 272.
Product Information
CAS number555-60-2
ATP CompetitiveN
FormYellow solid
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCarbonyl Cyanide m-Chlorophenylhydrazone, CAS 555-60-2, is a protonophore uncoupling agent for oxidative phosphorylation. Shown to be about 100-fold more effective than 2, 4-DNP.
Biological Information
Primary Targetcytochrome c oxydase
Primary Target IC<sub>50</sub>Kd = 270 nM in binding with cytochrome c oxidase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Safety Information according to GHS
RTECSFG5600000
Safety Information
R PhraseR: 20/21/22-36/37/38

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.
Global Trade Item Number
Catalogue Number GTIN
215911-250MG 04055977219241