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SCT066 BioTracker Tau filaments pFTAA Live Cell Dye

Live cell imaging dye for detection of disease-associated protein aggregates such as Amyloid protein deposits.

SCT066
1 mg  
Purchase on Sigma-Aldrich

Overview

Description
Catalogue NumberSCT066
DescriptionBioTracker Tau filaments pFTAA Live Cell Dye
OverviewProtein misfolding diseases are characterized by deposition of protein aggregates. Accumulation of protein deposits, so-called amyloid, is the histopathological hallmark of several devastating diseases, and the development of sensitive optical ligands to detect and characterize these disease-associated structures is of great interest.

The BioTracker Tau filaments pFTAA live cell dye is a novel fluorescent probe that can bind to and discriminate between amyloid-b (Aβ) plaques and tau neurofibrillary tangles (NFTs) in Alzheimer’s disease (AD)-like pathology in transgenic mouse brain tissue sections.

Spectral Properties
Excitation: 405 nm
Emissions: 550 nm

References
Klingstedt T et al. The Structural Basis for Optimal Performance of Oligothiophene-Based Fluorescent Amyloid Ligands: Conformational Flexibility is Essential for Spectral Assignment of a Diversity of Protein Aggregates. Chem Eur J. 2013, 19, 10179-10192.
Alternate Names
  • Live cell imaging probe
Product Information
Detection methodFluorescence
PresentationLyophilized
Applications
ApplicationLive cell imaging dye for detection of disease-associated protein aggregates such as Amyloid protein deposits.
Key Applications
  • Cell Based Assays
Application NotesLive cell fluorescent imaging
Biological Information
ConcentrationPlease refer to lot specific datasheet.
Molecular Weight704.65 g/mol
Product Usage Statements
Quality AssurancePurity: ≥ 98% confirmed by HNMR, LC-MS and HPLC and elemental analysis
Molar Mass: 704.65 g/mol
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStore BioTracker Tau filaments pFTAA Live Cell Dye at -20°C, desiccate and protect from light
Note: Centrifuge vial briefly to collect contents at bottom of vial before opening.
Packaging Information
Material Size1 mg
Global Trade Item Number
Catalogue Number GTIN
SCT066 04054839008405