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196805 Bax Channel Blocker - CAS 335165-69-0 - Calbiochem

A cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: (±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, iMAC1

Primary Target: Bax-channel forming activity
196805
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
335165-69-0C₁₉H₂₁Br₂N₃O

Products

Catalogue NumberPackaging Qty/Pack
196805-5MG Plastic ampoule 5 mg
Description
OverviewA cell-permeable dibromocarbazolo-piperazinyl derivative that displays anti-apoptotic properties. Effectively blocks Bid-induced cyctochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel-forming activity (IC50 = 520 nM in a liposome channel assay).
Catalogue Number196805
Brand Family Calbiochem®
Synonyms(±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, iMAC1
References
ReferencesPeixoto, P., et al. 2009. Biochem J. 423, 381.
Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.
Product Information
CAS number335165-69-0
ATP CompetitiveN
FormOff-white solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₁₉H₂₁Br₂N₃O
Chemical formulaC₁₉H₂₁Br₂N₃O
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetBax-channel forming activity
Primary Target IC<sub>50</sub>520 nM blocks Bid-induced cyctochrome c release from HeLa cell mitochondria by inhibiting Bax channel-forming activity in a liposome channel assay
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
196805-5MG 04055977206524

Documentation

Bax Channel Blocker - CAS 335165-69-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Bax Channel Blocker - CAS 335165-69-0 - Calbiochem Certificates of Analysis

TitleLot Number
196805

References

Reference overview
Peixoto, P., et al. 2009. Biochem J. 423, 381.
Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-July-2018 JSW
Synonyms(±)-1-(3,6-Dibromocarbazol-9-yl)-3-piperazin-1-yl-propan-2-ol, iMAC1
DescriptionA cell-permeable dibromocarbazole-piperazinyl derivative that displays anti-apoptotic properties. Reported to effectively block Bid-induced cytochrome c release from HeLa cell mitochondria (~80% inhibition at 5 µM) by inhibiting Bax channel activity.
FormOff-white solid
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
CAS number335165-69-0
Chemical formulaC₁₉H₂₁Br₂N₃O
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesPeixoto, P., et al. 2009. Biochem J. 423, 381.
Bombrun, A., et al. 2003. J. Med. Chem. 46, 4365.