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06-1425 Anti-phospho-TAK1 (Ser412) Antibody

Detect phospho-TAK1 (Ser412) using this Anti-phospho-TAK1 (Ser412) Antibody validated for use in WB.

Anti-phospho-TAK1 (Ser412) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: MAP Kinases Gene Symbol: MAP3K7, TAK1 UniProt Number: O43318
06-1425
200 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, MWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue Number06-1425
DescriptionAnti-phospho-TAK1 (Ser412) Antibody
Alternate Names
  • Mitogen-activated protein kinase kinase kinase 7
  • Transforming growth factor-beta-activated kinase 1
  • TGF-beta-activated kinase 1
Background InformationTAK1 MAPKKK is activated by TAB1 to transform growth factor-beta (TGF-beta) signaling. TAK1 can also associate with TAB1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. TAK1 has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways.
References
Product Information
FormatAffinity Purified
Control
  • Lambda phosphatase treated and untreated Murine RAW cell lysates
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect phospho-TAK1 (Ser412) using this Anti-phospho-TAK1 (Ser412) Antibody validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human TAK1 phosphorylated at Ser412.
EpitopePhosphorylated Ser412
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes TAK1 phosphorylated at Ser412.
Species Reactivity
  • Human
  • Mouse
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase mediates the signaling transduction induced by TGF beta and morphogenetic protein (BMP), and controls a variety of cell functions including transcription regulation and apoptosis. In response to IL-1, this protein forms a kinase complex including TRAF6, MAP3K7P1/TAB1 and MAP3K7P2/TAB2; this complex is required for the activation of nuclear factor kappa B. This kinase can also activate MAPK8/JNK, MAP2K4/MKK4, and thus plays a role in the cell response to environmental stresses. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq].
Gene Symbol
  • MAP3K7
  • TAK1
Modifications
  • Phosphorylation
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Component of a protein kinase signal transduction cascade. Mediator of TGF-beta signal transduction. Stimulates NF- kappa-B activation and the p38 MAPK pathway.

COFACTOR: Magnesium.

SIZE: 606 amino acids; 67196 Da

SUBUNIT: Binds both upstream activators and downstream substrates in multimolecular complexes. Interacts with MAP3K7IP1 and MAP3K7IP2. Interacts with PPM1L.

PTM: Association with MAP3K7IP1 promotes autophosphorylation and subsequent activation.

SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. & Contains 1 protein kinase domain.
Molecular Weight~70 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in lambda phosphatase treated and untreated Murine RAW cell lysates.

Western Blot Analysis: 1 µg/mL of this antibody detected TAK1 on 10 µg of lambda phosphatase treated and untreated Murine RAW cell lysates.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size200 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
06-1425 04053252630972

Documentation

Anti-phospho-TAK1 (Ser412) Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-phospho-TAK1 (Ser412) Antibody Certificates of Analysis

TitleLot Number
Anti-phospho-TAK1 (Ser412) - 2216894 2216894
Anti-phospho-TAK1 (Ser412) - 2324676 2324676
Anti-phospho-TAK1 (Ser412) - 3185657 3185657
Anti-phospho-TAK1 (Ser412) - 3728328 3728328
Anti-phospho-TAK1 (Ser412) - 3772442 3772442
Anti-phospho-TAK1 (Ser412) - 4041255 4041255
Anti-phospho-TAK1 (Ser412) - NRG1881309 NRG1881309
Anti-phospho-TAK1 (Ser412) -2611049 2611049
Anti-phospho-TAK1 (Ser412) -2638121 2638121
Anti-phospho-TAK1 (Ser412) Polyclonal Antibody 3090812
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