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06-1301 Anti-TTF2 Antibody

Use Anti-TTF2 Antibody (Sheep Polyclonal Antibody) validated in WB to detect TTF2 also known as Forkhead-related protein FKHL15, hyroid transcription factor 2.

Anti-TTF2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: FKHL15, FOXE2, HFKH4, HFKL5, OTTHUMP00000021756, TITF2, TTF-2, TTF2 UniProt Number: O00358
06-1301
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBShSerumPolyclonal Antibody
Description
Catalogue Number06-1301
DescriptionAnti-TTF2 Antibody
Alternate Names
  • Forkhead box protein E2
  • Forkhead-related protein FKHL15
  • HNF-3/fork head-like protein 5
  • Thyroid transcription factor 2
  • forkhead box E1
  • forkhead box E1 (thyroid transcription factor 2)
  • forkhead box E2
  • forkhead, drosophila, homolog-like 15
Background InformationTranscription termination factor, RNA polymerase II, also known as TTF2, is a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. TTF2 has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing. TTF2 can be found in the cytoplasm during interphase and relocates to the nucleus as the cell enters mitosis.
Product Information
FormatSerum
Control
  • Jurkat cell lysate
PresentationSheep polyclonal serum containing 0.05% sodium azide.
Applications
ApplicationUse Anti-TTF2 Antibody (Sheep Polyclonal Antibody) validated in WB to detect TTF2 also known as Forkhead-related protein FKHL15, hyroid transcription factor 2.
Key Applications
  • Western Blotting
Biological Information
ImmunogenHis-tagged recombinant protein corresponding to human TTF2.
HostSheep
SpecificityThis antibody recognizes TTF2.
Species Reactivity
  • Human
Species Reactivity NoteProven to react with human.
Mouse and rat (70% sequence homology).
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThis gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.
Gene Symbol
  • FKHL15
  • FOXE2
  • HFKH4
  • HFKL5
  • OTTHUMP00000021756
  • TITF2
  • TTF-2
  • TTF2
Purification MethodUnpurified
UniProt Number
UniProt SummaryFUNCTION: Probable transcription factor. Could be involved in thyroid gland organogenesis.
SUBCELLULAR LOCATION: Nucleus Potential.
TISSUE SPECIFICITY: Detected in adult brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, heart, colon, small intestine testis and thymus. Expression was strongest in heart and pancreas.
PTM: Phosphorylated By similarity.
POLYMORPHISM: An alanine stretch that varies from 12 to 19 residues is present. This polymorphisms can be used as a marker to study the role of FOXE1 in other cases of thyroid dysgenesis, especially in familial cases.
INVOLVEMENT IN DISEASE: Defects in FOXE1 are the cause of Bamforth-Lazarus syndrome [MIM:241850]. A disease associated with thyroid agenesis, cleft palate and choanal atresia.
SEQUENCE SIMILARITIES: Contains 1 fork-head DNA-binding domain.
SEQUENCE CAUTION: The sequence CAA64246.1 differs from that shown. Reason: Miscellaneous discrepancy. Several conflicts.
Molecular Weight~130 kDa
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in Jurkat cell lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected TTF2 in 10 µg of Jurkat cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at -20°C from date of receipt.
Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Packaging Information
Material Size100 µL
Global Trade Item Number
Catalogue Number GTIN
06-1301 04053252473562