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ABE125 Sigma-AldrichAnti-PRMT7 Antibody

Anti-PRMT7 Antibody detects level of PRMT7 & has been published & validated for use in PRMT7.

Anti-PRMT7 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Research Category: Epigenetics & Nuclear Function Research Sub-Category: Nuclear Receptors Gene Symbol: PRMT7 UniProt Number: Q9NVM4

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Key Spec Table

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB	Rb	Affinity Purified	Polyclonal Antibody

Description
Catalogue Number	ABE125
Description	Anti-PRMT7 Antibody
Alternate Names	Protein arginine N-methyltransferase 7 Histone-arginine N-methyltransferase PRMT7 Myelin basic protein]-arginine N-methyltransferase PRMT7
Background Information	PRMT7, also known as Protein arginine N-methyltransferase 7, Histone-arginine N-methyltransferase PRMT7 or Myelin basic protein-arginine N-methyltransferase PRMT7, and encoded by the gene PRMT7/KIAA1933, is an arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. PRMT7 specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins SmD1 (SNRPD1) and SmD3 (SNRPD3). Such methylation is required for the assembly and biogenesis of snRNP core particles. PRMT7 also mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s, and it plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s and thus leading to the recruitment of DNA methyltransferases to those sites. Finally, PRMT7 may also play a role in embryonic stem cell (ESC) pluripotency and is able to methylate histone H2A and myelin basic protein (MBP).

References

Product Information
Format	Affinity Purified
Presentation	Purified rabbit Polyclonal serum in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-PRMT7 Antibody detects level of PRMT7 & has been published & validated for use in PRMT7.
Key Applications	Western Blotting

Biological Information
Immunogen	GST-tagged recombinant protein corresponding to human PRMT7
Epitope	unknown
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Rabbit
Specificity	This antibody is expected to cross react with all isoforms based upon immunogen design.
Species Reactivity	Human
Species Reactivity Note	Human. Predicted to react with Chimpanzee, Horse, Feline, Bovine, Ferret based on 100% sequence homology.
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_061896
Gene Symbol	PRMT7
Purification Method	Affinity Purfied
UniProt Number	Q9NVM4
Molecular Weight	~75 kDa observed. Uniprot describes four isoforms at 79 kDa (Isoform 1), 62 kDa (Isoform 2), 73 kDa (Isoform 3), and 64 kDa (Isoform 4).

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in U2OS nuclear extract. Western Blotting Analysis: A 1:500 dilution of this antibody detected PRMT7 in 10 µg of U2OS nuclear extract.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt.

Packaging Information
Material Size	200 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
ABE125	04053252961113

Documentation

Anti-PRMT7 Antibody SDS

Title
Safety Data Sheet (SDS)

Anti-PRMT7 Antibody Certificates of Analysis

Title	Lot Number
Anti-PRMT7 - Q2388166	Q2388166
Anti-PRMT7 - 3186075	3186075
Anti-PRMT7 -2813461	2813461
Anti-PRMT7 Antibody - 3178577	3178577
Anti-PRMT7 Polyclonal Antibody	3008134

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