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ABD132 Anti-PHOX2B Antibody

Detect Phox2a using this rabbit polyclonal antibody, Anti-PHOX2B Antibody validated for use in western blotting.

Anti-PHOX2B Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Stem Cell Research Research Sub-Category: Pluripotent & Early Differentiation Gene Symbol: PHOX2B UniProt Number: Q99453
ABD132
100 µg  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABD132
DescriptionAnti-PHOX2B Antibody
Alternate Names
  • Paired-like homeobox 2B
  • Paired mesoderm homeobox protein 2B
  • PMX2B
  • Neuroblastoma Phox
  • NBLST2
  • NBPhox
  • PHOX2B homeodomain protein
Background InformationPaired mesoderm homeobox protein 2B (PHOX2B), also known as Neuroblastoma Phox (NBPhox), PHOX2B homeodomain protein, and Paired-like homeobox 2B is a paired-homeodomain transcription factor that maintains the noradrenergic phenotype during embryogenesis. PHOX2 proteins help regulate endogenous hydroxylases in neural crest cells and aid in sympathetic neuron generation. PHOX2A controls only the differentiation of the main noradrenergic center of the human brain, while PHOX2B is required for the differentiation of all central and nonperipheral noradrenergic centers. PHOX2B is expressed in neuroblastoma, brain and adrenal gland. PHOX2B defects can cause congenital central hypoventilation syndrome (CCHS) and susceptibility to neuroblastoma type 2 (NBLST2). PHOX2 regulation may have therapeutic potential in aging or degenerative noradrenergic neuron disorders.
References
Product Information
FormatAffinity Purified
Control
  • HEK293 cell lysate
PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Phox2a using this rabbit polyclonal antibody, Anti-PHOX2B Antibody validated for use in western blotting.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to human PHOX2B.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Gene Symbol
  • PHOX2B
Purification MethodAntigen Affinity Purified
UniProt Number
Molecular Weight~22 kDa observed. Uncharacterized bands may appear in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in HEK293 cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected PHOX2B in 15 µg of HEK293 cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABD132 04053252910050