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ABN1365-25UG Anti-OSTM1

Anti-OSTM1, Cat. No. ABN1365, is a highly specific rabbit polyclonal antibody that targets Osteopetrosis-associated transmembrane protein 1 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-OSTM1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Gene Symbol: OSTM1l, GL UniProt Number: Q86WC4
ABN1365-25UG
25 μg  
Purchase on Sigma-Aldrich

Overview

Replacement Information

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWB, IH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABN1365-25UG
DescriptionAnti-OSTM1
Alternate Names
  • Osteopetrosis-associated transmembrane protein 1
  • Chloride channel 7 beta subunit
Background InformationOsteopetrosis-associated transmembrane protein 1 (UniProt: Q86WC4; also known as Chloride channel 7 beta subunit) is encoded by the OSTM1 (also known as GL) gene (Gene ID: 28962) in human. Osteopetrosis-associated transmembrane protein 1 is a single-pass type I membrane protein that is required for osteoclast and melanocyte maturation and function. It is synthesized with a signal peptide of 31 amino acids, which is cleaved to produce the mature protein. Loss of OSTM1 leads to the most severe form of osteoporosis in mice and human. Although its role in bone chemistry is well established, several studies have shown its expression in neurons, microglia, and astrocytes. OSTM1-deficiecy in the central nervous system leads to gliosis with increased astrocyte cell population and microglia activation along with retinal degeneration at 2 to 3 weeks of age in mice. (Ref.: Ref.: Heraud, C., et al. 2014. J. Biol. Chem. 289(20); 13912-25).
References
Product Information
FormatAffinity Purified
PresentationPurified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine, 0.15M NaCl, pH 7.4 with 0.05% sodium azide.
Applications
ApplicationAnti-OSTM1, Cat. No. ABN1365, is a highly specific rabbit polyclonal antibody that targets Osteopetrosis-associated transmembrane protein 1 and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
Key Applications
  • Western Blotting
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected OSTM1 in human pancreas and human liver tissues.
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to 18 amino acids from the C-terminus region of human Osteopetrosis-associated transmembrane protein 1 (OSTM1).
ConcentrationPlease refer to lot specific datasheet.
HostRabbit
SpecificityThis rabbit polyclonal antibody detects Osteopetrosis-associated transmembrane protein 1 in human cells. It targets an epitope within 18 amino acids from the C-terminus region.
Species Reactivity
  • Human
Species Reactivity NoteHuman. Predicted to react with Baboon, Bovine based on 100% sequence homology.
Antibody TypePolyclonal Antibody
Gene Symbol
  • OSTM1l
  • GL
Purification MethodAffinity Purified
UniProt Number
Molecular Weight37 kDa observed. Uncharacterized bands may be observed in some lysate(s).
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blotting in human liver tissue lysate.
Western Blotting Analysis: 4 µg/mL of this antibody detected OSTM1 in 2 0 µg of human liver tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size25 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABN1365-25UG 04054839480218