Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

ABC67 Anti-Mitochondrial fission 1 protein (Fis1) Antibody

Detect Mitochondrial fission 1 protein (Fis1) using this Anti-Mitochondrial fission 1 protein (Fis1) Antibody validated for use in WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: FIS1, TTC11, CGI-135 UniProt Number: Q9Y3D6
ABC67
100 µg  
Purchase on Sigma-Aldrich

Special Offers

Overview

Replacement Information

Special Offers

100% Performance Guaranteed

Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
HWBRbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberABC67
DescriptionAnti-Mitochondrial fission 1 protein (Fis1) Antibody
Alternate Names
  • FIS1 homolog
  • hFis1
  • Tetratricopeptide repeat protein 11
  • TPR repeat protein 11
Background InformationMitochondrial fission 1 protein, hFIs1, is an overexpressed mammlian protein that is localized to the outer mitochondrial membrane of various cell types. It is involved in the fragmentation of the mitochondrial network and its perinuclear clustering, resulting in the release of cytochrome c from the mitochondrion, and apopotosis. It is known to mediate peroxisomal fission and also plays a critical role in histone function by demethylating Lys-4 of histone H3.
References
Product Information
FormatAffinity Purified
Control
  • Raji cell lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Mitochondrial fission 1 protein (Fis1) using this Anti-Mitochondrial fission 1 protein (Fis1) Antibody validated for use in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenKLH-conjugated-linear peptide corresponding to the cytoplasmic topological domain of human Mitochondrial fission 1 protein.
EpitopeCytoplasmic topological domain
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes the cytoplasmic topological domain of Mitochondrial fission 1 protein.
Species Reactivity
  • Human
Species Reactivity NoteDemonstrated to react with Human.
Other homologies: Rat and Mouse (83% sequence homology).
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe balance between fission and fusion regulates the morphology of mitochondria. TTC11 is a component of a mitochondrial complex that promotes mitochondrial fission.
Gene Symbol
  • FIS1
  • TTC11
  • CGI-135
Purification MethodAffinity Purfied
UniProt Number
UniProt SummaryFUNCTION: Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.

SUBUNIT STRUCTURE: Interacts with DNM1L/DLP1 through the TPR region. Interacts with MARCH5.

SUBCELLULAR LOCATION: Mitochondrion outer membrane; Single-pass membrane protein. Peroxisome membrane; Single-pass membrane protein.
Molecular Weight~17 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in Raji cell lysate.

Western Blot Analysis: 0.5 µg/mL of this antibody detected Mitochondrial fission 1 protein in 10 µg of Raji cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
ABC67 04053252633911

Documentation

Anti-Mitochondrial fission 1 protein (Fis1) Antibody SDS

Title

Safety Data Sheet (SDS) 

Anti-Mitochondrial fission 1 protein (Fis1) Antibody Certificates of Analysis

TitleLot Number
Anti-Mitochondrial fission 1 protein (Fis1) - 2420613 2420613
Anti-Mitochondrial fission 1 protein (Fis1) - 2279247 2279247
Anti-Mitochondrial fission 1 protein (Fis1) - 2300020 2300020
Anti-Mitochondrial fission 1 protein (Fis1) - 3160185 3160185
Anti-Mitochondrial fission 1 protein (Fis1) - 3205925 3205925
Anti-Mitochondrial fission 1 protein (Fis1) - 3271978 3271978
Anti-Mitochondrial fission 1 protein (Fis1) - NRG1944667 NRG1944667
Anti-Mitochondrial fission 1 protein (Fis1) -2676697 2676697
Anti-Mitochondrial fission 1 protein (Fis1) -2891879 2891879
Anti-Mitochondrial fission 1 protein (Fis1) Polyclonal Antibody 2962975
Show more