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MAB1567A4 Anti-MAG Antibody, clone 513, Alexa Fluor® 488 Conjugate

This Anti-MAG Antibody, clone 513, Alexa Fluor 488 Conjugate is validated for use in IC, IH for the detection of MAG.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: MAG, GMA UniProt Number: P20916
MAB1567A4
100 µL  
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Key Spec Table

Species ReactivityKey ApplicationsHostFormatAntibody Type
R, M, H, B, Ch, FgICC, IHCMAlexaFluor®488Monoclonal Antibody
Description
Catalogue NumberMAB1567A4
DescriptionAnti-MAG Antibody, clone 513, Alexa Fluor® 488 Conjugate
Alternate Names
  • Myelin-associated glycoprotein
  • Siglec-4a
Background InformationMyelin-associated glycoprotein (MAG), a member of the immunoglobulin superfamily, is a membrane glycoprotein of 100 kDa, and is thought to be involved in the process of myelination. Axonal regeneration in the adult central nervous system (CNS) is limited by two proteins in myelin, Nogo and MAG. MAG has been implicated in the inhibition of nerve regeneration in the CNS.
References
Product Information
FormatAlexaFluor®488
Control
  • Adult mouse brain tissue
PresentationPurified mouse monoclonal IgG1 conjugated to Alexa Fluor® 488 in PBS with 0.1% sodium azide and 15 mg/mL BSA.
Quality LevelMQ100
Applications
ApplicationThis Anti-MAG Antibody, clone 513, Alexa Fluor 488 Conjugate is validated for use in IC, IH for the detection of MAG.
Key Applications
  • Immunocytochemistry
  • Immunohistochemistry
Application NotesImmunocytochemistry Analysis: A 1:100 dilution from a representative lot detected MAG in rat E18 primary cortex cells.
Biological Information
ImmunogenL2 epitope carrying glycoprotein extract of 1-2 day old chicken brain
Clone513
HostMouse
IsotypeIgG1
Species Reactivity
  • Rat
  • Mouse
  • Human
  • Bovine
  • Chicken
  • Frog
Species Reactivity NoteDemonstrated to react with Rat and Mouse. Predicted to react with Human, Bovine, Chicken, and Frog based on 100% sequence homology.
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a type I membrane protein and member of the immunoglobulin superfamily. It is thought to be involved in the process of myelination. It is a lectin that binds to sialylated glycoconjugates and mediates certain myelin-neuron cell-cell interactions. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.
Gene Symbol
  • MAG
  • GMA
Purification MethodProtein A Purfied
UniProt Number
UniProt SummaryFUNCTION: Adhesion molecule in postnatal neural development that mediates sialic-acid dependent cell-cell interactions between neuronal and myelinating cells. Preferentially binds to alpha2,3- linked sialic acid (By similarity).

SIZE: 626 amino acids; 69069 Da

SUBUNIT: Binds to RTN4R (By similarity).

SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.

SIMILARITY: Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. & Contains 4 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.
Molecular Weight69 kDa calculated
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry in adult mouse brain tissue.

Immunohistochemistry Analysis: A 1:100 dilution of this antibody detected MAG in adult mouse brain tissue.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain refrigerated at 2-8 °C protected from light in undiluted aliquots for up to 6 months from date of receipt.
Packaging Information
Material Size100 µL
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
MAB1567A4 04053252754999

Documentation

Anti-MAG Antibody, clone 513, Alexa Fluor® 488 Conjugate SDS

Title

Safety Data Sheet (SDS) 

Anti-MAG Antibody, clone 513, Alexa Fluor® 488 Conjugate Certificates of Analysis

TitleLot Number
Anti-MAG, clone 513 -2523262 2523262
Anti-MAG, clone 513 Alexa Fluor® 488 Conjugate 2965134
Anti-MAG, clone 513, Alexa Fluor® 488 Conjugate 3077986
Anti-MAG, clone 513, Alexa Fluor® 488 Conjugate - 2377302 2377302
Anti-MAG, clone 513, -2618345 2618345
Anti-MAG, clone 513, -2694647 2694647
Anti-MAG, clone 513, Alexa Fluor#174; 488 Conjugate - NRG1922535 NRG1922535
Anti-MAG, clone 513, Alexa Fluor® 488 Conjugate 3111603
Anti-MAG, clone 513, Alexa Fluor® 488 Conjugate 2961738
Anti-MAG, clone 513, Alexa Fluor® 488 Conjugate 2949960
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