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MABF1553 Sigma-AldrichAnti-CD8a (Mouse), redFluor™ 710, clone 53-6.7 Antibody

Anti-CD8a (Mouse), redFluor™ 710, clone 53-6.7 Antibody detects level of CD8a and has been published and validated for use in Flow Cytometry.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA

Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: CD8a UniProt Number: P01731

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Key Spec Table

Species Reactivity	Key Applications	Host	Format	Antibody Type
M	FC	R	redFluor™ 710	Monoclonal Antibody

Description
Catalogue Number	MABF1553
Description	Anti-CD8a (Mouse), redFluor™ 710, clone 53-6.7 Antibody
Alternate Names	T-cell surface glycoprotein CD8 alpha chain T-cell surface glycoprotein Lyt-2 CD8a CD8a
Background Information	The 53-6.7 antibody reacts with the 32-34 kDa alpha subunit of mouse CD8, known as CD8a or CD8 alpha. CD8a can form a homodimer (CD8 alpha-alpha), but is more commonly expressed as a heterodimer with a second chain known as CD8b or CD8 beta. CD8 acts as a co-receptor in antigen recognition and subsequent T cell activation that is initiated upon binding of the T cell receptor (TCR) to antigen-bearing MHC Class I molecules. The cytoplasmic domains of CD8 provide binding sites for the tyrosine kinase lck, facilitating intracellular signaling events that lead to T cell activation, development, and cytotoxic effector functions. CD8+ cytotoxic T cells (CTLs) play an important role in inducing cell death of tumor cells, as well as cells infected by virus, bacteria or parasites.The 53-6.7 antibody is widely used as a phenotypic marker for mouse CD8a expression on cytotoxic T cells, thymocytes, as well as on certain cell types that do not also express the TCR, including some NK cells and lymphoid dendritic cells.

Product Information
Format	redFluor™ 710
Presentation	Purified Rat monoclonal containing 10 mM NaH2PO4, 150 mM NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2.
Quality Level	MQ100

Applications
Application	Anti-CD8a (Mouse), redFluor™ 710, clone 53-6.7 Antibody detects level of CD8a and has been published and validated for use in Flow Cytometry.
Key Applications	Flow Cytometry

Biological Information
Immunogen	Immunogen information for this antibody is proprietary information.
Clone	53-6.7
Concentration	Please refer to lot specific datasheet.
Host	Rat
Species Reactivity	Mouse
Antibody Type	Monoclonal Antibody
Gene Symbol	CD8a
Purification Method	Purified by size-exclusion chromatography
UniProt Number	P01731

Product Usage Statements
Quality Assurance	This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. Flow Cytometry Analysis: 0.25 μg from a representative lot detected CD8a in one million C57Bl/6 splenocytes.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at 2-8°C from date of receipt. Note: It is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.

Packaging Information
Material Size	100 μg

Global Trade Item Number
Catalogue Number	GTIN
MABF1553	04055977292619

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