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506166 p53 Modulator, CP-31398 - CAS 259199-65-0 - Calbiochem

A cell-permeable styrylquinazoline compound that protects wild-type p53 against heat-induced denaturation and locks newly synthesized mutant p53 in an active conformation.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: p53 Activator V, Nʹ-(2-(2-(4-Methoxyphenyl)ethenyl)-4-quinazolinyl)-N,N-dimethyl-1,3-propanediamine, 2HCl

506166
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
259199-65-0C₂₂H₂₆N₄O • 2HCl
Description
Overview

This product has been discontinued.



A cell-permeable styrylquinazoline compound that protects wild-type p53 against heat-induced denaturation and locks newly synthesized mutant p53 in an active conformation as determined by mAb PAb1620 (Cat. No. OP33) reactivity and DNA binding in both intact cells and in cell-free assays. Shown to induce p21WAF1 and Bax expressions and apoptosis (2.5 to 10 µg/ml) in mutant p53-carrying, but not p53-null, cells. Reported to suppress the growths of human cancer cells, A375-S2 and DLD-1, in mice (100 mg/kg/day; i.p.) and Azoxymethane-induced colorectal cancer in F344 rats (supplemented at 100 to 400 ppm in animal feed) in vivo. Unlike PRIMA-1 (Cat. No. 530050), CP-31398 directly targets the DBD (DNA binding domain) of p53. Also known to induce p53-independent cytotoxicity in cultures at concentrations above 15 µg/ml.
Catalogue Number506166
Brand Family Calbiochem®
Synonymsp53 Activator V, Nʹ-(2-(2-(4-Methoxyphenyl)ethenyl)-4-quinazolinyl)-N,N-dimethyl-1,3-propanediamine, 2HCl
References
ReferencesRao, C.V., et al. 2009. Cancer Res. 69, 8175.
Demma, M.J., et al. 2004. J. Biol. Chem. 279, 45887.
Wang, W., et al. 2003. Mol. Cell. Biol. 23, 2171.
Wischhusen, J., et al. 2003. Oncogene 22, 8233.
Rippin, T.M., et al. 2002. Oncogene 21, 2119.
Foster, B.A., et al. 1999. Science 286, 2507.
Product Information
CAS number259199-65-0
FormYellow solid
Hill FormulaC₂₂H₂₆N₄O • 2HCl
Chemical formulaC₂₂H₂₆N₄O • 2HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Applications
Biological Information
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsSolution unstable. Prepare solution just prior to use.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
506166 0

Documentation

p53 Modulator, CP-31398 - CAS 259199-65-0 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

p53 Modulator, CP-31398 - CAS 259199-65-0 - Calbiochem Certificates of Analysis

TitleLot Number
506166

References

Reference overview
Rao, C.V., et al. 2009. Cancer Res. 69, 8175.
Demma, M.J., et al. 2004. J. Biol. Chem. 279, 45887.
Wang, W., et al. 2003. Mol. Cell. Biol. 23, 2171.
Wischhusen, J., et al. 2003. Oncogene 22, 8233.
Rippin, T.M., et al. 2002. Oncogene 21, 2119.
Foster, B.A., et al. 1999. Science 286, 2507.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-June-2010 RFH
Synonymsp53 Activator V, Nʹ-(2-(2-(4-Methoxyphenyl)ethenyl)-4-quinazolinyl)-N,N-dimethyl-1,3-propanediamine, 2HCl
DescriptionA cell-permeable styrylquinazoline compound that protects wild-type p53 against heat-induced denaturation and locks newly synthesized mutant p53 in an active conformation as determined by mAb PAb1620 (Cat. No. OP33) reactivity and DNA binding in both intact cells and in cell-free assays. Shown to induce p21WAF1 and Bax expressions and apoptosis (2.5 to 10 µg/ml) in mutant p53-carrying, but not p53-null, cells. Reported to suppress the growths of human cancer cells, A375-S2 and DLD-1, in mice (100 mg/kg/day; i.p.) and Azoxymethane-induced colorectal cancer in F344 rats (supplemented at 100 to 400 ppm in animal feed) in vivo. Unlike PRIMA-1 (Cat. No. 530050), CP-31398 directly targets the DBD (DNA binding domain) of p53. Also known to induce p53-independent cytotoxicity in cultures at concentrations above 15 µg/ml.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number259199-65-0
Chemical formulaC₂₂H₂₆N₄O • 2HCl
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsSolution unstable. Prepare solution just prior to use.
Toxicity Standard Handling
ReferencesRao, C.V., et al. 2009. Cancer Res. 69, 8175.
Demma, M.J., et al. 2004. J. Biol. Chem. 279, 45887.
Wang, W., et al. 2003. Mol. Cell. Biol. 23, 2171.
Wischhusen, J., et al. 2003. Oncogene 22, 8233.
Rippin, T.M., et al. 2002. Oncogene 21, 2119.
Foster, B.A., et al. 1999. Science 286, 2507.