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407721 m-Iodobenzylguanidine, Hemisulfate - CAS 80663-95-2 - Calbiochem

A cell-permeable norepinephrine analog that displays antiproliferative and proapoptotic properties.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Iodobenzylguanidine, Hemisulfate, MIBG

Primary Target: Arginine-dependent mono-ADP-ribosylation
407721
  
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
80663-95-2C₈H₁₀IN₃ • 1/2H₂SO₄
Description
Overview

This product has been discontinued.



A cell-permeable norepinephrine analog that displays antiproliferative and proapoptotic properties. Reported to competitively inhibit arginine-dependent mono-ADP-ribosylation, impair mitochondrial respiration, stimulate glycolysis, and prevent terminal differentiation of skeletal myoblasts reversibly. Readily taken up by tissues rich in sympathetic neurons and neuroendocrine neoplasm via norepinephrine transporters (NET). Inhibits the phosphorylation of the Rho effector, PRK1/2 with no effect on the stimulation of MAP and PI3-kinases.
Catalogue Number407721
Brand Family Calbiochem®
Synonyms3-Iodobenzylguanidine, Hemisulfate, MIBG
References
ReferencesYau, L., et al. 2004. Exp. Cell Res. 301, 320.
Yau, L., et al. 2003. Eur. J. Biochem. 270, 101.
Hopfner, M., et al. 2002. Int. J. Cancer 101, 210.
Smets, L., et al. 1988. Leuk. Res. 12, 737.
Product Information
CAS number80663-95-2
ATP CompetitiveY
FormColorless to white solid
Hill FormulaC₈H₁₀IN₃ • 1/2H₂SO₄
Chemical formulaC₈H₁₀IN₃ • 1/2H₂SO₄
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetArginine-dependent mono-ADP-ribosylation
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
407721 0

Documentation

m-Iodobenzylguanidine, Hemisulfate - CAS 80663-95-2 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

m-Iodobenzylguanidine, Hemisulfate - CAS 80663-95-2 - Calbiochem Certificates of Analysis

TitleLot Number
407721

References

Reference overview
Yau, L., et al. 2004. Exp. Cell Res. 301, 320.
Yau, L., et al. 2003. Eur. J. Biochem. 270, 101.
Hopfner, M., et al. 2002. Int. J. Cancer 101, 210.
Smets, L., et al. 1988. Leuk. Res. 12, 737.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-July-2008 RFH
Synonyms3-Iodobenzylguanidine, Hemisulfate, MIBG
DescriptionA cell-permeable norepinephrine analog that displays antiproliferative and proapoptotic properties. Reported to competitively inhibit arginine-dependent mono-ADP-ribosylation, impair mitochondrial respiration, stimulate glycolysis, and prevent terminal differentiation of skeletal myoblasts reversibly. Readily taken up by tissues rich in sympathetic neurons and neuroendocrine neoplasm via norepinephrine transporters (NET). Inhibits the phosphorylation of the Rho effector, PRK1/2 with no effect on the stimulation of MAP and PI-3 kinases.
FormColorless to white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number80663-95-2
Chemical formulaC₈H₁₀IN₃ • 1/2H₂SO₄
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityH₂O (20 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesYau, L., et al. 2004. Exp. Cell Res. 301, 320.
Yau, L., et al. 2003. Eur. J. Biochem. 270, 101.
Hopfner, M., et al. 2002. Int. J. Cancer 101, 210.
Smets, L., et al. 1988. Leuk. Res. 12, 737.