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344038 cFMS Receptor Inhibitor III - CAS 959861-21-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(3,4-Dimethylanilino)-7-(4-(methylsulfonyl)phenyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor III

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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
959861-21-3C₂₅H₂₃N₃O₃S
Description
Overview

This product has been discontinued.



A cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC50 = 8 nM). It is 100-fold more potent in inhibiting the cFMS-dependent growth of M-NSF-60 cells than the cFMS-independent growth of NSO cells (IC50 = 0.1 and 10 µM, respectively).
Catalogue Number344038
Brand Family Calbiochem®
Synonyms4-(3,4-Dimethylanilino)-7-(4-(methylsulfonyl)phenyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor III
References
ReferencesSmalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6257.
Product Information
CAS number959861-21-3
FormYellow solid
Hill FormulaC₂₅H₂₃N₃O₃S
Chemical formulaC₂₅H₂₃N₃O₃S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
344038 0

Documentation

cFMS Receptor Inhibitor III - CAS 959861-21-3 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

cFMS Receptor Inhibitor III - CAS 959861-21-3 - Calbiochem Certificates of Analysis

TitleLot Number
344038

References

Reference overview
Smalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6257.
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-May-2011 RFH
Synonyms4-(3,4-Dimethylanilino)-7-(4-(methylsulfonyl)phenyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor III
DescriptionA cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC50 = 8 nM). It is 100-fold more potent in inhibiting the cFMS-dependent growth of M-NSF-60 cells than the cFMS-independent growth of NSO cells (IC50 = 0.1 and 10 µM, respectively).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number959861-21-3
Chemical formulaC₂₅H₂₃N₃O₃S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSmalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6257.