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662105 Ubiquitin E1 Inhibitor, PYR-41 - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₁₇H₁₃N₃O₇ • 3H₂O

Products

Catalogue NumberPackaging Qty/Pack
662105-25MG Plastic ampoule 25 mg
Description
OverviewA cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50 <10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
Catalogue Number662105
Brand Family Calbiochem®
Synonyms4-(4-(5-Nitro-furan-2-ylmethylene)-3,5-dioxo-pyrazolidin-1-yl)-benzoic acid ethyl ester, trihydrate, Ubiquitin-Activating Enzyme E1 Inhibitor, PYR-41
References
ReferencesYang, Y., et al. 2007. Cancer Res. 67, 9472.
Product Information
FormDark purple solid
Hill FormulaC₁₇H₁₃N₃O₇ • 3H₂O
Chemical formulaC₁₇H₁₃N₃O₇ • 3H₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationUbiquitin E1 Inhibitor, PYR-41, CAS 418805-02-4, is a cell-permeable, irreversible inhibitor of ubiquitin-activating enzyme E1 activity (IC50 less than 10 µM in cell-free E1 ubiquitination reactions).
Biological Information
Purity≥90% by HPLC (sum of two isomers)
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 22-24/25-36-45

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
662105-25MG 04055977261196