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616373 Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem

Tpl2 Kinase Inhibitor, CAS 871307-18-5, is a cell-permeable, potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine

Primary Target: Tpl2 Kinase
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616373
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
871307-18-5C₂₁H₁₄ClFN₆

Products

Catalogue NumberPackaging Qty/Pack
616373-1MG Plastic ampoule 1 mg
Description
OverviewA cell-permeable naphthyridine compound that acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM). Displays significant selectivity over other related kinases (IC50 = 5, >40, 110, 180, >400 and >400 µM for EGFR, MEK, MK2, p38, Src, and PKC, respectively). Shown to inhibit LPS-induced TNF-α production both from primary human monocytes and in whole blood (IC50 = 700 nM and 8.5 µM, respectively).
Catalogue Number616373
Brand Family Calbiochem®
Synonyms4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
References
ReferencesGavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5288.
Product Information
CAS number871307-18-5
ATP CompetitiveY
FormYellow solid
Hill FormulaC₂₁H₁₄ClFN₆
Chemical formulaC₂₁H₁₄ClFN₆
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationTpl2 Kinase Inhibitor, CAS 871307-18-5, is a cell-permeable, potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM).
Biological Information
Primary TargetTpl2 Kinase
Primary Target IC<sub>50</sub>50 nM against Tpl2 kinase
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
Catalogue Number GTIN
616373-1MG 04055977186239

Documentation

Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem SDS

Title

Safety Data Sheet (SDS) 

Tpl2 Kinase Inhibitor - CAS 871307-18-5 - Calbiochem Certificates of Analysis

TitleLot Number
616373

References

Reference overview
Gavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5288.

Brochure

Title
Pathways and Biomarkers of Toll-like Receptor (TLR) Signaling

Posters

Title
Human Kinome & InhibitorSelect™ Libraries
Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-October-2007 JSW
Synonyms4-(3-Chloro-4-fluorophenylamino)-6-(pyridin-3-yl-methylamino)-3-cyano-[1,7]-naphthyridine
DescriptionA cell-permeable naphthyridine compound that acts as a potent, reversible, and ATP-competitive inhibitor of Tpl2 kinase (IC50 = 50 nM). Displays significant selectivity over other related kinases (IC50 = 5, >40, 110, 180, >400 and >400 µM for EGFR, MEK, MK2, p38, Src, and PKC, respectively). Shown to inhibit LPS-induced TNF-α production both from primary human monocytes and in whole blood (IC50 = 700 nM and 8.5 µM, respectively).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number871307-18-5
Chemical formulaC₂₁H₁₄ClFN₆
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesGavrin, L.K., et al. 2005. Bioorg. Med. Chem. Lett. 15, 5288.